Talk:Comparative genomics
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[edit] evo-devo
Would contributors to this article mind commenting here, [1] and perhaps even contributing to the EVO-Devo article? Thanks, Slrubenstein | Talk 15:52, 29 August 2006 (UTC)
[edit] Rewriting
There are a number of problems with this article, it is a good introduction/starting point, but it does need to be brought up to scratch to actually reflect the current field. Most changes are basic grammar and praseology, but there are some other important ones: Gene Finding: This term is obsolete now, the term is gene prediction. 'Gene finding is an important application of comparative genomics, as is discovery of new, non-coding functional elements of the genome.' This sentence is cumbersome and compresses two individually important topics. 'Finally, those elements that are unimportant to the evolutionary success of the organism will be unconserved (selection is neutral).' - Misleading, most mutations are neutral.
'Having come a long way from its initial use of finding functional proteins, comparative genomics is now concentrating on finding regulatory regions and siRNA molecules. Recently, it has been discovered that distantly related species often share long conserved stretches of DNA that do not appear to code for any protein. It is unknown at this time what function such ultra-conserved regions serve.'This is just completely underdeveloped
Furthermore, the article is not fully structured and feels like a stub. I do not mean to mock the work of the authors, but it is at best a cursory over-view and deserves a much more in-depth analysis.
I intend to re-write the article soon. If anyone would like to comment or give suggestions, I would appreciate it.
Mike Dacre (talk) 15:46, 22 March 2008 (UTC)
