COL19A1

From Wikipedia, the free encyclopedia

Collagen, type XIX, alpha 1

Identifiers

COL19A1; COL9A1L; D6S228E

External IDs

OMIM: 120165 MGI: 1095415 HomoloGene: 55608

Gene ontology
Molecular Function:	• extracellular matrix structural constituent • protein binding, bridging
Cellular Component:	• collagen • cytoplasm
Biological Process:	• skeletal development • phosphate transport • striated muscle development • cell-cell adhesion • extracellular matrix organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001858 (mRNA)
NP_001849 (protein)

NM_007733 (mRNA)
NP_031759 (protein)

Location

Chr 6: 70.63 - 70.98 Mb

Chr 1: 24.22 - 24.54 Mb

Pubmed search

[1]

[2]

Collagen, type XIX, alpha 1, also known as COL19A1, is a human gene.^[1]

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced.^[1]

[edit] References

^ ^a ^b Entrez Gene: COL19A1 collagen, type XIX, alpha 1.

[edit] Further reading

Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans.". Genomics 13 (3): 884-6. PMID 1639419.
Inoguchi K, Yoshioka H, Khaleduzzaman M, Ninomiya Y (1995). "The mRNA for alpha 1(XIX) collagen chain, a new member of FACITs, contains a long unusual 3' untranslated region and displays many unique splicing variants.". J. Biochem. 117 (1): 137-46. PMID 7775380.
Myers JC, Sun MJ, D'Ippolito JA, et al. (1993). "Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain.". Gene 123 (2): 211-7. PMID 7916703.
Myers JC, Yang H, D'Ippolito JA, et al. (1994). "The triple-helical region of human type XIX collagen consists of multiple collagenous subdomains and exhibits limited sequence homology to alpha 1(XVI).". J. Biol. Chem. 269 (28): 18549-57. PMID 8034603.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Gerecke DR, Olson PF, Koch M, et al. (1997). "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13.". Genomics 41 (2): 236-42. doi:10.1006/geno.1997.4638. PMID 9143499.
Sumiyoshi H, Inoguchi K, Khaleduzzaman M, et al. (1997). "Ubiquitous expression of the alpha1(XIX) collagen gene (Col19a1) during mouse embryogenesis becomes restricted to a few tissues in the adult organism.". J. Biol. Chem. 272 (27): 17104-11. PMID 9202028.
Khaleduzzaman M, Sumiyoshi H, Ueki Y, et al. (1998). "Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family.". Genomics 45 (2): 304-12. doi:10.1006/geno.1997.4921. PMID 9344653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Myers JC, Li D, Amenta PS, et al. (2003). "Type XIX collagen purified from human umbilical cord is characterized by multiple sharp kinks delineating collagenous subdomains and by intermolecular aggregates via globular, disulfide-linked, and heparin-binding amino termini.". J. Biol. Chem. 278 (34): 32047-57. doi:10.1074/jbc.M304629200. PMID 12788917.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Käpylä J, Jäälinoja J, Tulla M, et al. (2005). "The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix.". J. Biol. Chem. 279 (49): 51677-87. doi:10.1074/jbc.M409412200. PMID 15383545.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.