COG5

From Wikipedia, the free encyclopedia

Component of oligomeric golgi complex 5

Identifiers

COG5; GOLTC1; GTC90

External IDs

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• membrane • Golgi transport complex
Biological Process:	• intra-Golgi vesicle-mediated transport • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_006348 (mRNA)
NP_006339 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 7: 106.63 - 106.99 Mb

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Pubmed search

[1]

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Component of oligomeric golgi complex 5, also known as COG5, is a human gene.^[1]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: COG5 component of oligomeric golgi complex 5.

[edit] Further reading

Walter DM, Paul KS, Waters MG (1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport.". J. Biol. Chem. 273 (45): 29565–76. PMID 9792665.
Chen X, Bykhovskaya Y, Tidow N, et al. (2000). "The familial mediterranean fever protein interacts and colocalizes with a putative Golgi transporter.". Proc. Soc. Exp. Biol. Med. 224 (1): 32–40. PMID 10782044.
Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMID 11980916.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
Oka T, Vasile E, Penman M, et al. (2005). "Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.". J. Biol. Chem. 280 (38): 32736–45. doi:10.1074/jbc.M505558200. PMID 16051600.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.