COG1

From Wikipedia, the free encyclopedia

Component of oligomeric golgi complex 1

Identifiers

COG1; DKFZp762L1710; KIAA1381; LDLB

External IDs

OMIM: 606973 MGI: 1333873 HomoloGene: 8411

Gene ontology
Molecular Function:	• protein binding • protein transporter activity
Cellular Component:	• membrane • Golgi transport complex
Biological Process:	• intra-Golgi vesicle-mediated transport • Golgi organization and biogenesis • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018714 (mRNA)
NP_061184 (protein)

NM_013581 (mRNA)
NP_038609 (protein)

Location

Chr 17: 68.7 - 68.72 Mb

Chr 11: 113.47 - 113.48 Mb

Pubmed search

[1]

[2]

Component of oligomeric golgi complex 1, also known as COG1, is a human gene.^[1]

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: COG1 component of oligomeric golgi complex 1.

[edit] Further reading

Chatterton JE, Hirsch D, Schwartz JJ, et al. (1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex.". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 915-20. PMID 9927668.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955-61. doi:10.1074/jbc.M202326200. PMID 11929878.
Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.". J. Cell Biol. 157 (3): 405-15. doi:10.1083/jcb.200202016. PMID 11980916.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640-8. doi:10.1074/jbc.M400662200. PMID 15047703.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ungar D, Oka T, Vasile E, et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex.". J. Biol. Chem. 280 (38): 32729-35. doi:10.1074/jbc.M504590200. PMID 16020545.
Vasile E, Oka T, Ericsson M, et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex.". Exp. Cell Res. 312 (16): 3132-41. doi:10.1016/j.yexcr.2006.06.005. PMID 16857184.