CoB-CoM heterodisulfide reductase

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In enzymology, a CoB---CoM heterodisulfide reductase (EC 1.8.98.1) is an enzyme that catalyzes the chemical reaction

coenzyme B + coenzyme M + methanophenazine $\rightleftharpoons$ N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O₃-phospho-L-threonine + dihydromethanophenazine

The 3 substrates of this enzyme are coenzyme B, coenzyme M, and methanophenazine, whereas its two products are [[N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine]] and dihydromethanophenazine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with other, known, acceptors. The systematic name of this enzyme class is coenzyme B:coenzyme M:methanophenazine oxidoreductase. Other names in common use include heterodisulfide reductase, and soluble heterodisulfide reductase. This enzyme participates in folate biosynthesis.

[edit] References

IUBMB entry for 1.8.98.1
BRENDA references for 1.8.98.1 (Recommended.)
PubMed references for 1.8.98.1
PubMed Central references for 1.8.98.1
Google Scholar references for 1.8.98.1
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Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U (1998). "Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1". J. Bacteriol. 180: 2027–32. PMID 9555882.
Simianu M, Murakami E, Brewer JM, Ragsdale SW (1998). "Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila". Biochemistry. 37: 10027–39. doi:10.1021/bi9726483. PMID 9665708.
Murakami E, Deppenmeier U, Ragsdale SW (2001). "Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila". J. Biol. Chem. 276: 2432–9. doi:10.1074/jbc.M004809200. PMID 11034998.