Coactivation (Transcription)

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Coactivation is a process by which the transcription of RNA is increased. Proteins called coactivators are recruited to DNA-binding transcription factors through their activation domains and increase transcription by relaxing the chromatin structure to allow greater access to a gene or by bringing in components of the basal transcription complex needed for transcription to occur. Examples of coactivators are CBP, p300, Mediator and SWI/SNF.^[1]

[edit] References

1. ^ Spielgelman B, Heinrich R (2004). "Biological Control through Regulated Transcriptional Coactivators". Cell 119 (2): 157–67. doi:10.1016/j.cell.2004.09.037. PMID 15479634.