COASY

From Wikipedia, the free encyclopedia

Coenzyme A synthase

Identifiers

COASY; NBP; PPAT; DPCK; FLJ35179; UKR1; pOV-2

External IDs

OMIM: 609855 MGI: 1918993 HomoloGene: 11889

Gene ontology
Molecular Function:	• nucleotide binding • dephospho-CoA kinase activity • pantetheine-phosphate adenylyltransferase activity • ATP binding • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• biosynthetic process • coenzyme A biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042529 (mRNA)
NP_001035994 (protein)

NM_027896 (mRNA)
NP_082172 (protein)

Location

Chr 17: 37.97 - 37.97 Mb

Chr 11: 100.9 - 100.9 Mb

Pubmed search

[1]

[2]

Coenzyme A synthase, also known as COASY, is a human gene.^[1]

[edit] References

^ Entrez Gene: COASY Coenzyme A synthase.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Montagna M, Serova O, Sylla BS, et al. (1996). "A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase.". Hum. Genet. 96 (5): 532-8. PMID 8529999.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Daugherty M, Polanuyer B, Farrell M, et al. (2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.". J. Biol. Chem. 277 (24): 21431-9. doi:10.1074/jbc.M201708200. PMID 11923312.
Zhyvoloup A, Nemazanyy I, Babich A, et al. (2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis.". J. Biol. Chem. 277 (25): 22107-10. doi:10.1074/jbc.C200195200. PMID 11980892.
Aghajanian S, Worrall DM (2002). "Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase).". Biochem. J. 365 (Pt 1): 13-8. doi:10.1042/BJ20020569. PMID 11994049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhyvoloup A, Nemazanyy I, Panasyuk G, et al. (2004). "Subcellular localization and regulation of coenzyme A synthase.". J. Biol. Chem. 278 (50): 50316-21. doi:10.1074/jbc.M307763200. PMID 14514684.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Nemazanyy I, Panasyuk G, Zhyvoloup A, et al. (2005). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism.". FEBS Lett. 578 (3): 357-62. doi:10.1016/j.febslet.2004.10.091. PMID 15589845.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Nemazanyy I, Panasyuk G, Breus O, et al. (2006). "Identification of a novel CoA synthase isoform, which is primarily expressed in the brain.". Biochem. Biophys. Res. Commun. 341 (4): 995-1000. doi:10.1016/j.bbrc.2006.01.051. PMID 16460672.