CNTN2

From Wikipedia, the free encyclopedia

Contactin 2 (axonal)

Identifiers

CNTN2; AXT; DKFZp781D102; FLJ42746; MGC157722; TAG-1; TAX; TAX1

External IDs

OMIM: 190197 MGI: 104518 HomoloGene: 3720

Gene ontology
Molecular Function:	• protein binding • GPI anchor binding
Cellular Component:	• plasma membrane • integral to plasma membrane • membrane • integral to membrane • axon
Biological Process:	• neuron migration • cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005076 (mRNA)
NP_005067 (protein)

NM_177129 (mRNA)
NP_796103 (protein)

Location

Chr 1: 203.28 - 203.31 Mb

Chr 1: 134.34 - 134.37 Mb

Pubmed search

[1]

[2]

Contactin 2 (axonal), also known as CNTN2, is a human gene.^[1]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.^[1]

[edit] References

^ ^a ^b Entrez Gene: CNTN2 contactin 2 (axonal).

[edit] Further reading

Walsh FS, Doherty P (1992). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system.". Cell Biol. Int. Rep. 15 (11): 1151-66. PMID 1838307.
Kuhn TB, Stoeckli ET, Condrau MA, et al. (1991). "Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4).". J. Cell Biol. 115 (4): 1113-26. PMID 1720120.
Dodd J, Morton SB, Karagogeos D, et al. (1990). "Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons.". Neuron 1 (2): 105-16. PMID 3272160.
Kenwrick S, Leversha M, Rooke L, et al. (1993). "Localization of the human TAX-1 gene to 1q32.1: a region implicated in microcephaly and Van der Woude syndrome.". Hum. Mol. Genet. 2 (9): 1461-2. PMID 8242070.
Tsiotra PC, Karagogeos D, Theodorakis K, et al. (1994). "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1.". Genomics 18 (3): 562-7. PMID 8307567.
Rader C, Stoeckli ET, Ziegler U, et al. (1993). "Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1.". Eur. J. Biochem. 215 (1): 133-41. PMID 8344273.
Hasler TH, Rader C, Stoeckli ET, et al. (1993). "cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1.". Eur. J. Biochem. 211 (1-2): 329-39. PMID 8425542.
Kozlov SV, Giger RJ, Hasler T, et al. (1996). "The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter.". Genomics 30 (2): 141-8. doi:10.1006/geno.1995.9892. PMID 8586412.
Yoshihara Y, Kawasaki M, Tamada A, et al. (1996). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily.". J. Neurobiol. 28 (1): 51-69. doi:10.1002/neu.480280106. PMID 8586965.
Milev P, Maurel P, Häring M, et al. (1996). "TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM.". J. Biol. Chem. 271 (26): 15716-23. PMID 8663515.
Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y.". Mol. Cell. Biol. 17 (3): 1236-43. PMID 9032250.
Williams H, Schachner M, Wang B, Kenwrick S (1998). "Radiation hybrid mapping of the genes for tenascin-R (TNR), phosducin (PDC), laminin C1 (LAMC1), and TAX in 1q25-q32.". Genomics 46 (1): 165-6. doi:10.1006/geno.1997.4994. PMID 9403076.
Malhotra JD, Tsiotra P, Karagogeos D, Hortsch M (1999). "Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion.". J. Biol. Chem. 273 (50): 33354-9. PMID 9837910.
Freigang J, Proba K, Leder L, et al. (2000). "The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion.". Cell 101 (4): 425-33. PMID 10830169.
Rickman DS, Tyagi R, Zhu XX, et al. (2001). "The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas.". Cancer Res. 61 (5): 2162-8. PMID 11280781.
Pavlou O, Theodorakis K, Falk J, et al. (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members.". Mol. Cell. Neurosci. 20 (3): 367-81. PMID 12139915.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Traka M, Goutebroze L, Denisenko N, et al. (2003). "Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.". J. Cell Biol. 162 (6): 1161-72. doi:10.1083/jcb.200305078. PMID 12975355.
Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.". Biochem. Biophys. Res. Commun. 313 (3): 654-65. PMID 14697242.