CNTN1

From Wikipedia, the free encyclopedia

Contactin 1

Identifiers

CNTN1; F3; GP135

External IDs

OMIM: 600016 MGI: 105980 HomoloGene: 7274

Gene ontology
Molecular Function:	• protein binding • GPI anchor binding
Cellular Component:	• membrane fraction • membrane
Biological Process:	• cell adhesion • Notch signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001843 (mRNA)
NP_001834 (protein)

NM_007727 (mRNA)
NP_031753 (protein)

Location

Chr 12: 39.51 - 39.75 Mb

Chr 15: 91.96 - 92.17 Mb

Pubmed search

[1]

[2]

Contactin 1, also known as CNTN1, is a human gene.^[1]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CNTN1 contactin 1.

[edit] Further reading

Walsh FS, Doherty P (1992). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system.". Cell Biol. Int. Rep. 15 (11): 1151-66. PMID 1838307.
Peles E, Schlessinger J, Grumet M (1998). "Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling.". Trends Biochem. Sci. 23 (4): 121-4. PMID 9584610.
Olive S, Dubois C, Schachner M, Rougon G (1995). "The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum.". J. Neurochem. 65 (5): 2307-17. PMID 7595520.
Peles E, Nativ M, Campbell PL, et al. (1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.". Cell 82 (2): 251-60. PMID 7628014.
Berglund EO, Ranscht B (1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12.". Genomics 21 (3): 571-82. doi:10.1006/geno.1994.1316. PMID 7959734.
Reid RA, Bronson DD, Young KM, Hemperly JJ (1994). "Identification and characterization of the human cell adhesion molecule contactin.". Brain Res. Mol. Brain Res. 21 (1-2): 1-8. PMID 8164510.
Yoshihara Y, Kawasaki M, Tamada A, et al. (1996). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily.". J. Neurobiol. 28 (1): 51-69. doi:10.1002/neu.480280106. PMID 8586965.
Sakurai T, Lustig M, Nativ M, et al. (1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta.". J. Cell Biol. 136 (4): 907-18. PMID 9049255.
Xiao ZC, Taylor J, Montag D, et al. (1997). "Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11.". Eur. J. Neurosci. 8 (4): 766-82. PMID 9081628.
Xiao ZC, Hillenbrand R, Schachner M, et al. (1997). "Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R.". J. Neurosci. Res. 49 (6): 698-709. PMID 9335257.
Pierre K, Rougon G, Allard M, et al. (1998). "Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons.". J. Neurosci. 18 (14): 5333-43. PMID 9651216.
Revest JM, Faivre-Sarrailh C, Maeda N, et al. (1999). "The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells.". Eur. J. Neurosci. 11 (4): 1134-47. PMID 10103110.
Berglund EO, Murai KK, Fredette B, et al. (2000). "Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression.". Neuron 24 (3): 739-50. PMID 10595523.
Pierre K, Dupouy B, Allard M, et al. (2001). "Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.". Eur. J. Neurosci. 14 (4): 645-56. PMID 11556889.
Kazarinova-Noyes K, Malhotra JD, McEwen DP, et al. (2001). "Contactin associates with Na+ channels and increases their functional expression.". J. Neurosci. 21 (19): 7517-25. PMID 11567041.
Pavlou O, Theodorakis K, Falk J, et al. (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members.". Mol. Cell. Neurosci. 20 (3): 367-81. PMID 12139915.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Garwood J, Heck N, Reichardt F, Faissner A (2003). "Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.". J. Biol. Chem. 278 (26): 24164-73. doi:10.1074/jbc.M211721200. PMID 12700241.