CMPK

From Wikipedia, the free encyclopedia

Cytidylate kinase

PDB rendering based on 1tev.

Available structures: 1tev

Identifiers

Symbol(s)

CMPK; UMPK; RP11-511I2.1; UMP-CMPK

External IDs

OMIM: 191710 MGI: 1913838 HomoloGene: 32308

Gene ontology
Molecular Function:	• nucleotide binding • cytidylate kinase activity • uridine kinase activity • ATP binding • kinase activity • transferase activity • phosphotransferase activity, phosphate group as acceptor
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • pyrimidine ribonucleotide biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016308 (mRNA)
NP_057392 (protein)

NM_025647 (mRNA)
NP_079923 (protein)

Location

Chr 1: 47.57 - 47.62 Mb

Chr 4: 114.46 - 114.49 Mb

Pubmed search

[1]

[2]

Cytidylate kinase, also known as CMPK, is a human gene.^[1]

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis (Liou et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CMPK cytidylate kinase.

[edit] Further reading

Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. PMID 1286669.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993.". Electrophoresis 14 (11): 1216–22. PMID 8313870.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme.". Mol. Pharmacol. 56 (3): 562–9. PMID 10462544.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Pearman AT, Castro-Faria-Neto HC, McIntyre TM, et al. (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region.". Life Sci. 69 (20): 2361–70. PMID 11681623.
Liou JY, Dutschman GE, Lam W, et al. (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.". Cancer Res. 62 (6): 1624–31. PMID 11912132.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pasti C, Gallois-Montbrun S, Munier-Lehmann H, et al. (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates.". Eur. J. Biochem. 270 (8): 1784–90. PMID 12694191.
Segura-Peña D, Sekulic N, Ort S, et al. (2004). "Substrate-induced conformational changes in human UMP/CMP kinase.". J. Biol. Chem. 279 (32): 33882–9. doi:10.1074/jbc.M401989200. PMID 15163660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hsu CH, Liou JY, Dutschman GE, Cheng YC (2005). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium.". Mol. Pharmacol. 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID 15550676.
Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.". J. Neurochem. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Topalis D, Kumamoto H, Amaya Velasco MF, et al. (2007). "Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.". FEBS J. 274 (14): 3704–14. doi:10.1111/j.1742-4658.2007.05902.x. PMID 17608725.