CLIP1

From Wikipedia, the free encyclopedia

CAP-GLY domain containing linker protein 1

PDB rendering based on 2cp5.

Available structures: 2cp5, 2cp6, 2cp7

Identifiers

Symbol(s)

CLIP1; CLIP; CLIP-170; CLIP170; CYLN1; MGC131604; RSN

External IDs

OMIM: 179838 MGI: 1928401 HomoloGene: 74455

Gene ontology
Molecular Function:	• nucleic acid binding • protein binding • microtubule binding • zinc ion binding • protein homodimerization activity • metal ion binding
Cellular Component:	• kinetochore • endosome • cytoplasmic microtubule • intermediate filament
Biological Process:	• mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002956 (mRNA)
NP_002947 (protein)

NM_019765 (mRNA)
NP_062739 (protein)

Location

Chr 12: 121.32 - 121.47 Mb

Chr 5: 123.84 - 123.94 Mb

Pubmed search

[1]

[2]

CAP-GLY domain containing linker protein 1, also known as CLIP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1.

[edit] Further reading

Galjart N (2005). "CLIPs and CLASPs and cellular dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 487-98. doi:10.1038/nrm1664. PMID 15928712.
Pierre P, Scheel J, Rickard JE, Kreis TE (1992). "CLIP-170 links endocytic vesicles to microtubules.". Cell 70 (6): 887-900. PMID 1356075.
Bilbe G, Delabie J, Brüggen J, et al. (1992). "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease.". EMBO J. 11 (6): 2103-13. PMID 1600942.
Pierre P, Pepperkok R, Kreis TE (1995). "Molecular characterization of two functional domains of CLIP-170 in vivo.". J. Cell. Sci. 107 ( Pt 7): 1909-20. PMID 7983157.
Hilliker C, Delabie J, Speleman F, et al. (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus.". Cytogenet. Cell Genet. 65 (3): 172-6. PMID 8222754.
Griparic L, Keller TC (1998). "Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle.". Biochim. Biophys. Acta 1405 (1-3): 35-46. PMID 9784600.
Perez F, Diamantopoulos GS, Stalder R, Kreis TE (1999). "CLIP-170 highlights growing microtubule ends in vivo.". Cell 96 (4): 517-27. PMID 10052454.
Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.". Cell 104 (6): 923-35. PMID 11290329.
Coquelle FM, Caspi M, Cordelières FP, et al. (2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway.". Mol. Cell. Biol. 22 (9): 3089-102. PMID 11940666.
Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (2002). "The cytoplasmic linker protein CLIP-170 is a human autoantigen.". Clin. Exp. Immunol. 127 (3): 533-8. PMID 11966772.
Fukata M, Watanabe T, Noritake J, et al. (2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.". Cell 109 (7): 873-85. PMID 12110184.
Choi JH, Bertram PG, Drenan R, et al. (2003). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase.". EMBO Rep. 3 (10): 988-94. doi:10.1093/embo-reports/kvf197. PMID 12231510.
Sahin U, Neumann F, Tureci O, et al. (2003). "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells.". Blood 100 (12): 4139-45. doi:10.1182/blood.V100.12.4139. PMID 12433698.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Goodson HV, Skube SB, Stalder R, et al. (2004). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms.". Cell Motil. Cytoskeleton 55 (3): 156-73. doi:10.1002/cm.10114. PMID 12789661.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells.". Oncogene 22 (27): 4243-56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Watanabe T, Wang S, Noritake J, et al. (2005). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.". Dev. Cell 7 (6): 871-83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.