CLGN

From Wikipedia, the free encyclopedia

Calmegin

Identifiers

External IDs

OMIM: 601858 MGI: 107472 HomoloGene: 68392

Gene ontology
Molecular Function:	• calcium ion binding • unfolded protein binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• protein folding • single fertilization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004362 (mRNA)
NP_004353 (protein)

NM_009904 (mRNA)
NP_034034 (protein)

Location

Chr 4: 141.53 - 141.57 Mb

Chr 8: 86.28 - 86.32 Mb

Pubmed search

[1]

[2]

Calmegin, also known as CLGN, is a human gene.^[1]

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLGN calmegin.

[edit] Further reading

Watanabe D, Yamada K, Nishina Y, et al. (1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development.". J. Biol. Chem. 269 (10): 7744–9. PMID 8126001.
Ikawa M, Wada I, Kominami K, et al. (1997). "The putative chaperone calmegin is required for sperm fertility.". Nature 387 (6633): 607–11. doi:10.1038/42484. PMID 9177349.
Tanaka H, Ikawa M, Tsuchida J, et al. (1998). "Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone.". Gene 204 (1-2): 159–63. PMID 9434179.
Yoshinaga K, Tanii I, Toshimori K (1999). "Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis.". Arch. Histol. Cytol. 62 (3): 283–93. PMID 10495883.
Ikawa M, Nakanishi T, Yamada S, et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.". Dev. Biol. 240 (1): 254–61. doi:10.1006/dbio.2001.0462. PMID 11784061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kim DH, Shim JS, Kwon HJ (2005). "Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase.". Exp. Mol. Med. 37 (5): 492–6. PMID 16264275.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.