CLEC7A

From Wikipedia, the free encyclopedia

C-type lectin domain family 7, member A

Identifiers

CLEC7A; BGR; CLECSF12; DECTIN1

External IDs

OMIM: 606264 MGI: 1861431 HomoloGene: 49606

Gene ontology
Molecular Function:	• sugar binding • pattern recognition receptor activity • MHC protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• phagocytosis, recognition • inflammatory response • carbohydrate mediated signaling • antibacterial humoral response • antifungal humoral response • T cell activation • defense response to protozoan • innate immune response • reduction of virulence

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_022570 (mRNA)
NP_072092 (protein)

XM_001003642 (mRNA)
XP_001003642 (protein)

Location

Chr 12: 10.16 - 10.17 Mb

n/a

Pubmed search

[1]

[2]

C-type lectin domain family 7, member A, also known as CLEC7A, is a human gene.^[1]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLEC7A C-type lectin domain family 7, member A.

[edit] Further reading

Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585–90. PMID 10508765.
Brown GD (2006). "Dectin-1: a signalling non-TLR pattern-recognition receptor.". Nat. Rev. Immunol. 6 (1): 33–43. doi:10.1038/nri1745. PMID 16341139.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Ariizumi K, Shen GL, Shikano S, et al. (2000). "Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning.". J. Biol. Chem. 275 (26): 20157–67. doi:10.1074/jbc.M909512199. PMID 10779524.
Yokota K, Takashima A, Bergstresser PR, Ariizumi K (2001). "Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1.". Gene 272 (1-2): 51–60. PMID 11470510.
Hermanz-Falcón P, Arce I, Roda-Navarro P, Fernández-Ruiz E (2001). "Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells.". Immunogenetics 53 (4): 288–95. PMID 11491532.
Brown GD, Gordon S (2001). "Immune recognition. A new receptor for beta-glucans.". Nature 413 (6851): 36–7. doi:10.1038/35092620. PMID 11544516.
Willment JA, Gordon S, Brown GD (2001). "Characterization of the human beta -glucan receptor and its alternatively spliced isoforms.". J. Biol. Chem. 276 (47): 43818–23. doi:10.1074/jbc.M107715200. PMID 11567029.
Sobanov Y, Bernreiter A, Derdak S, et al. (2002). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex.". Eur. J. Immunol. 31 (12): 3493–503. PMID 11745369.
Grünebach F, Weck MM, Reichert J, Brossart P (2002). "Molecular and functional characterization of human Dectin-1.". Exp. Hematol. 30 (11): 1309–15. PMID 12423684.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ahrén IL, Eriksson E, Egesten A, Riesbeck K (2003). "Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors.". Am. J. Respir. Cell Mol. Biol. 29 (5): 598–605. doi:10.1165/rcmb.2002-0138OC. PMID 12689921.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Taylor PR, Brown GD, Herre J, et al. (2004). "The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.". J. Immunol. 172 (2): 1157–62. PMID 14707091.
Mantegazza AR, Barrio MM, Moutel S, et al. (2005). "CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells.". Blood 104 (4): 1183–90. doi:10.1182/blood-2004-01-0104. PMID 15130945.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
de la Rosa G, Yáñez-Mó M, Samaneigo R, et al. (2005). "Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation.". J. Leukoc. Biol. 77 (5): 699–709. doi:10.1189/jlb.0904529. PMID 15728245.
Willment JA, Marshall AS, Reid DM, et al. (2005). "The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.". Eur. J. Immunol. 35 (5): 1539–47. doi:10.1002/eji.200425725. PMID 15816015.