CLEC4A

From Wikipedia, the free encyclopedia

C-type lectin domain family 4, member A

Identifiers

CLEC4A; CLECSF6; DCIR; DDB27; HDCGC13P; LLIR

External IDs

OMIM: 605306 MGI: 1349412 HomoloGene: 49291

Gene ontology
Molecular Function:	• transmembrane receptor activity • sugar binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• immune response • cell adhesion • cell surface receptor linked signal transduction • antimicrobial humoral response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016184 (mRNA)
NP_057268 (protein)

NM_011999 (mRNA)
NP_036129 (protein)

Location

Chr 12: 8.17 - 8.18 Mb

Chr 6: 123.09 - 123.11 Mb

Pubmed search

[1]

[2]

C-type lectin domain family 4, member A, also known as CLEC4A, is a human gene.^[1]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLEC4A C-type lectin domain family 4, member A.

[edit] Further reading

Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585–90. PMID 10508765.
Bates EE, Fournier N, Garcia E, et al. (1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif.". J. Immunol. 163 (4): 1973–83. PMID 10438934.
Huang X, Yuan Z, Chen G, et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants.". Biochem. Biophys. Res. Commun. 281 (1): 131–40. doi:10.1006/bbrc.2001.4322. PMID 11178971.
Richard M, Veilleux P, Rouleau M, et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation.". J. Leukoc. Biol. 71 (5): 871–80. PMID 11994513.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
Richard M, Thibault N, Veilleux P, et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.". Biochem. Biophys. Res. Commun. 310 (3): 767–73. PMID 14550269.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Richard M, Thibault N, Veilleux P, et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2.". Mol. Immunol. 43 (10): 1716–21. doi:10.1016/j.molimm.2005.10.006. PMID 16360206.
Lorentzen JC, Flornes L, Eklöw C, et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors.". Arthritis Rheum. 56 (8): 2620–32. doi:10.1002/art.22813. PMID 17665455.