CLEC2D

From Wikipedia, the free encyclopedia

C-type lectin domain family 2, member D

Identifiers

CLEC2D; CLAX; LLT1; OCIL

External IDs

OMIM: 605659 MGI: 2136934 HomoloGene: 88817

Gene ontology
Molecular Function:	• transmembrane receptor activity • sugar binding
Cellular Component:	• membrane fraction • integral to plasma membrane
Biological Process:	• cell surface receptor linked signal transduction • antimicrobial humoral response

Orthologs

Human

Mouse

n/a

Refseq

NM_001004420 (mRNA)
NP_001004420 (protein)

NM_053165 (mRNA)
NP_444395 (protein)

Location

n/a

Chr 6: 128.63 - 128.64 Mb

Pubmed search

[1]

[2]

C-type lectin domain family 2, member D, also known as CLEC2D, is a human gene.^[1]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLEC2D C-type lectin domain family 2, member D.

[edit] Further reading

Boles KS, Barten R, Kumaresan PR, et al. (1999). "Cloning of a new lectin-like receptor expressed on human NK cells.". Immunogenetics 50 (1-2): 1-7. PMID 10541800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors.". Nat. Immunol. 4 (8): 801-7. doi:10.1038/ni954. PMID 12858173.
Hu YS, Zhou H, Myers D, et al. (2004). "Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.". J. Bone Miner. Res. 19 (1): 89-99. PMID 14753741.
Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527-32. doi:10.1073/pnas.0308304101. PMID 14990792.
Mathew PA, Chuang SS, Vaidya SV, et al. (2004). "The LLT1 receptor induces IFN-gamma production by human natural killer cells.". Mol. Immunol. 40 (16): 1157-63. PMID 15104121.
Gange CT, Quinn JM, Zhou H, et al. (2004). "Characterization of sugar binding by osteoclast inhibitory lectin.". J. Biol. Chem. 279 (28): 29043-9. doi:10.1074/jbc.M312518200. PMID 15123656.
Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.". J. Immunol. 175 (12): 7791-5. PMID 16339512.
Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.". J. Immunol. 175 (12): 7796-9. PMID 16339513.