CLDN1

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Claudin 1
Identifiers
Symbol(s) CLDN1; CLD1; ILVASC; SEMP1
External IDs OMIM: 603718 MGI: 1276109 HomoloGene: 9620
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9076 12737
Ensembl ENSG00000163347 ENSMUSG00000022512
Uniprot O95832 Q4FJV3
Refseq NM_021101 (mRNA)
NP_066924 (protein)		 NM_016674 (mRNA)
NP_057883 (protein)
Location Chr 3: 191.51 - 191.52 Mb Chr 16: 26.27 - 26.29 Mb
Pubmed search [1] [2]

Claudin 1, also known as CLDN1, is a human gene. It belongs to the group of claudins.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.[1]

[edit] References

  1. ^ Entrez Gene: CLDN1 claudin 1.

[edit] Further reading

  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. PMID 10690502. 
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. PMID 11247307. 
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. 
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. PMID 12231346. 
  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. PMID 12475568. 
  • Swisshelm K, Macek R, Kubbies M (2005). "Role of claudins in tumorigenesis.". Adv. Drug Deliv. Rev. 57 (6): 919–28. doi:10.1016/j.addr.2005.01.006. PMID 15820559. 
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity.". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675. 
  • Ye J (2007). "Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.". PLoS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMID 17784784. 
  • Furuse M, Fujita K, Hiiragi T, et al. (1998). "Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.". J. Cell Biol. 141 (7): 1539–50. PMID 9647647. 
  • Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. PMID 9892664. 
  • Swisshelm K, Machl A, Planitzer S, et al. (1999). "SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily.". Gene 226 (2): 285–95. PMID 9931503. 
  • Furuse M, Sasaki H, Tsukita S (1999). "Manner of interaction of heterogeneous claudin species within and between tight junction strands.". J. Cell Biol. 147 (4): 891–903. PMID 10562289. 
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.". J. Cell Biol. 147 (6): 1351–63. PMID 10601346. 
  • Halford S, Spencer P, Greenwood J, et al. (2000). "Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids.". Cytogenet. Cell Genet. 88 (3-4): 217. PMID 10828592. 
  • Krämer F, White K, Kubbies M, et al. (2000). "Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer.". Hum. Genet. 107 (3): 249–56. PMID 11071387. 
  • Miyamori H, Takino T, Kobayashi Y, et al. (2001). "Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases.". J. Biol. Chem. 276 (30): 28204–11. doi:10.1074/jbc.M103083200. PMID 11382769. 
  • Hamazaki Y, Itoh M, Sasaki H, et al. (2002). "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule.". J. Biol. Chem. 277 (1): 455–61. doi:10.1074/jbc.M109005200. PMID 11689568. 
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