CLDN11

From Wikipedia, the free encyclopedia

Claudin 11 (oligodendrocyte transmembrane protein)

Identifiers

CLDN11; OSP; OTM

External IDs

OMIM: 601326 MGI: 106925 HomoloGene: 4093

Gene ontology
Molecular Function:	• structural molecule activity • identical protein binding
Cellular Component:	• tight junction • membrane • integral to membrane
Biological Process:	• cell adhesion • spermatogenesis • axon ensheathment • calcium-independent cell-cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005602 (mRNA)
NP_005593 (protein)

NM_008770 (mRNA)
NP_032796 (protein)

Location

Chr 3: 171.62 - 171.63 Mb

Chr 3: 31.34 - 31.36 Mb

Pubmed search

[1]

[2]

Claudin 11 (oligodendrocyte transmembrane protein), also known as CLDN11, is a human gene.^[1] It belongs to the group of claudins.

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein).

[edit] Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57-76. PMID 10690502.
Bronstein JM, Tiwari-Woodruff S, Buznikov AG, Stevens DB (2000). "Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease.". J. Neurosci. Res. 59 (6): 706-11. PMID 10700007.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93-8. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285-93. doi:10.1038/35067088. PMID 11283726.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531-6. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1-44. PMID 12475568.
Bronstein JM, Kozak CA, Chen XN, et al. (1997). "Chromosomal localization of murine and human oligodendrocyte-specific protein genes.". Genomics 34 (2): 255-7. doi:10.1006/geno.1996.0278. PMID 8661061.
Bronstein JM, Popper P, Micevych PE, Farber DB (1996). "Isolation and characterization of a novel oligodendrocyte-specific protein.". Neurology 47 (3): 772-8. PMID 8797478.
Shafit-Zagardo B, Kress Y, Zhao ML, Lee SC (1999). "A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions.". J. Neurochem. 73 (6): 2531-7. PMID 10582615.
Gow A, Southwood CM, Li JS, et al. (2000). "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice.". Cell 99 (6): 649-59. PMID 10612400.
Bronstein JM, Chen K, Tiwari-Woodruff S, Kornblum HI (2000). "Developmental expression of OSP/claudin-11.". J. Neurosci. Res. 60 (3): 284-90. PMID 10797530.
Tiwari-Woodruff SK, Buznikov AG, Vu TQ, et al. (2001). "OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes.". J. Cell Biol. 153 (2): 295-305. PMID 11309411.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.