CLDN10

From Wikipedia, the free encyclopedia

Claudin 10

Identifiers

CLDN10; CPETRL3; OSP-L

External IDs

MGI: 1913101 HomoloGene: 5076

Gene ontology
Molecular Function:	• structural molecule activity • identical protein binding
Cellular Component:	• integral to plasma membrane • tight junction • membrane • integral to membrane
Biological Process:	• cell adhesion • calcium-independent cell-cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006984 (mRNA)
NP_008915 (protein)

NM_021386 (mRNA)
NP_067361 (protein)

Location

Chr 13: 94.88 - 95.03 Mb

Chr 14: 117.7 - 117.79 Mb

Pubmed search

[1]

[2]

Claudin 10, also known as CLDN10, is a human gene.^[1] It belongs to the group of claudins.

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Two alternatively spliced transcript variants that encode different isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLDN10 claudin 10.

[edit] Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. PMID 10690502.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. PMID 12475568.
Kubota K, Furuse M, Sasaki H, et al. (2000). "Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions.". Curr. Biol. 9 (18): 1035–8. PMID 10508613.
Christian SL, McDonough J, Liu Cy CY, et al. (2002). "An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.". Genomics 79 (5): 635–56. doi:10.1006/geno.2002.6765. PMID 11991713.
Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes.". Eur. J. Cell Biol. 81 (5): 253–63. PMID 12067061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Cheung ST, Leung KL, Ip YC, et al. (2005). "Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma.". Clin. Cancer Res. 11 (2 Pt 1): 551–6. PMID 15701840.