Citryl-CoA lyase

From Wikipedia, the free encyclopedia

In enzymology, a citryl-CoA lyase (EC 4.1.3.34) is an enzyme that catalyzes the chemical reaction

(3S)-citryl-CoA acetyl-CoA + oxaloacetate

Hence, this enzyme has one substrate, (3S)-citryl-CoA, and two products, acetyl-CoA and oxaloacetate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming). This enzyme is also called (3S)-citryl-CoA oxaloacetate-lyase. This enzyme participates in citrate cycle (tca cycle).

[edit] References

• IUBMB entry for 4.1.3.34
• BRENDA references for 4.1.3.34 (Recommended.)
• PubMed references for 4.1.3.34
• PubMed Central references for 4.1.3.34
• Google Scholar references for 4.1.3.34
• Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate". Eur. J. Biochem. 80: 479–88. PMID 336371. 
• Lill U, Schreil A, Eggerer H (1982). "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125: 645–50. PMID 6749502. 

[edit] External links

The CAS registry number for this enzyme class is 131095-35-7.

• IUBMB entry for 4.1.3.34

• KEGG entry for 4.1.3.34

• BRENDA entry for 4.1.3.34

• NiceZyme view of 4.1.3.34

• EC2PDB: PDB structures for 4.1.3.34

• PRIAM entry for 4.1.3.34

• PUMA2 entry for 4.1.3.34

• IntEnz: Integrated Enzyme entry for 4.1.3.34

• MetaCyc entry for 4.1.3.34

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008816: citryl-CoA lyase

• AMIGO entry for GO code 0008816: citryl-CoA lyase