Citrate (pro-3S)-lyase

From Wikipedia, the free encyclopedia

In enzymology, a citrate (pro-3S)-lyase (EC 4.1.3.6) is an enzyme that catalyzes the chemical reaction

citrate $\rightleftharpoons$ acetate + oxaloacetate

Hence, this enzyme has one substrate, citrate, and two products, acetate and oxaloacetate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, and citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]. This enzyme participates in citrate cycle (tca cycle) and two-component system - general.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1U5H, 1U5V, 1Z6K, and 2HJ0.

[edit] References

IUBMB entry for 4.1.3.6
BRENDA references for 4.1.3.6 (Recommended.)
PubMed references for 4.1.3.6
PubMed Central references for 4.1.3.6
Google Scholar references for 4.1.3.6
DAGLEY S, DAWES EA (1955). "Citridesmolase: its properties and mode of action". Biochim. Biophys. Acta. 17: 177–84. PMID 13239657.
Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate". Eur. J. Biochem. 80: 479–88. PMID 336371.