Citramalyl-CoA lyase

From Wikipedia, the free encyclopedia

In enzymology, a citramalyl-CoA lyase (EC 4.1.3.25) is an enzyme that catalyzes the chemical reaction

(3S)-citramalyl-CoA acetyl-CoA + pyruvate

Hence, this enzyme has one substrate, (3S)-citramalyl-CoA, and two products, acetyl-CoA and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming). Other names in common use include citramalyl coenzyme A lyase, (+)-CMA-CoA lyase, and (3S)-citramalyl-CoA pyruvate-lyase. This enzyme participates in pyruvate metabolism and c5-branched dibasic acid metabolism.

[edit] References

• IUBMB entry for 4.1.3.25
• BRENDA references for 4.1.3.25 (Recommended.)
• PubMed references for 4.1.3.25
• PubMed Central references for 4.1.3.25
• Google Scholar references for 4.1.3.25
• Cooper RA, Kornberg HL (1964). "The utilization of itaconate by Pseudomonas sp". Biochem. J. 91: 82–91. PMID 4284209. 
• Dimroth P, Buckel W, Loyal R, Eggerer H (1977). "Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase". Eur. J. Biochem. 80: 469–77. doi:10.1111/j.1432-1033.1977.tb11902.x. PMID 923590. 

[edit] External links

The CAS registry number for this enzyme class is 37290-68-9.

• IUBMB entry for 4.1.3.25

• KEGG entry for 4.1.3.25

• BRENDA entry for 4.1.3.25

• NiceZyme view of 4.1.3.25

• EC2PDB: PDB structures for 4.1.3.25

• PRIAM entry for 4.1.3.25

• PUMA2 entry for 4.1.3.25

• IntEnz: Integrated Enzyme entry for 4.1.3.25

• MetaCyc entry for 4.1.3.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047777: citramalyl-CoA lyase

• AMIGO entry for GO code 0047777: citramalyl-CoA lyase