CIT (gene)

From Wikipedia, the free encyclopedia

Citron (rho-interacting, serine/threonine kinase 21)

Identifiers

CIT; CRIK; KIAA0949; STK21

External IDs

OMIM: 605629 MGI: 105313 HomoloGene: 21404

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • small GTPase regulator activity • protein binding • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding • metal ion binding
Cellular Component:	• ruffle • intracellular • cytoplasm • actin cytoskeleton
Biological Process:	• mitotic sister chromatid segregation • cytokinesis • protein amino acid phosphorylation • cell cycle • mitotic metaphase/anaphase transition • intracellular signaling cascade • multicellular organismal development • spermatogenesis • nervous system development • dendrite development • cell differentiation • generation of neurons • negative regulation of dendrite morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007174 (mRNA)
NP_009105 (protein)

NM_007708 (mRNA)
NP_031734 (protein)

Location

Chr 12: 118.61 - 118.8 Mb

Chr 5: 116.11 - 116.27 Mb

Pubmed search

[1]

[2]

Citron (rho-interacting, serine/threonine kinase 21), also known as CIT, is a human gene.^[1]

[edit] References

^ Entrez Gene: CIT citron (rho-interacting, serine/threonine kinase 21).

[edit] Further reading

Madaule P, Furuyashiki T, Reid T, et al. (1996). "A novel partner for the GTP-bound forms of rho and rac.". FEBS Lett. 377 (2): 243-8. PMID 8543060.
Di Cunto F, Calautti E, Hsiao J, et al. (1998). "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron.". J. Biol. Chem. 273 (45): 29706-11. PMID 9792683.
Zhang W, Vazquez L, Apperson M, Kennedy MB (1999). "Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus.". J. Neurosci. 19 (1): 96-108. PMID 9870942.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63-70. PMID 10231032.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661-9. doi:10.1038/76615. PMID 10862698.
Di Cunto F, Imarisio S, Hirsch E, et al. (2000). "Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.". Neuron 28 (1): 115-27. PMID 11086988.
Liu H, Di Cunto F, Imarisio S, Reid LM (2003). "Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes.". J. Biol. Chem. 278 (4): 2541-8. doi:10.1074/jbc.M210391200. PMID 12411428.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ozeki Y, Tomoda T, Kleiderlein J, et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289-94. doi:10.1073/pnas.0136913100. PMID 12506198.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Irobi J, Van Impe K, Seeman P, et al. (2004). "Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy.". Nat. Genet. 36 (6): 597-601. doi:10.1038/ng1328. PMID 15122253.
Lyons-Warren A, Chang JJ, Balkissoon R, et al. (2005). "Evidence of association between bipolar disorder and Citron on chromosome 12q24.". Mol. Psychiatry 10 (9): 807-9. doi:10.1038/sj.mp.4001703. PMID 15983625.
Gruneberg U, Neef R, Li X, et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis.". J. Cell Biol. 172 (3): 363-72. doi:10.1083/jcb.200511061. PMID 16431929.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346-51. doi:10.1038/nature04569. PMID 16541075.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Paramasivam M, Chang YJ, LoTurco JJ (2007). "ASPM and citron kinase co-localize to the midbody ring during cytokinesis.". Cell Cycle 6 (13): 1605-12. PMID 17534152.