CIR (gene)

From Wikipedia, the free encyclopedia

CBF1 interacting corepressor

Identifiers

External IDs

OMIM: 605228 MGI: 1914185 HomoloGene: 3589

Gene ontology
Molecular Function:	• transcription factor activity • transcription corepressor activity • protein binding
Cellular Component:	• histone deacetylase complex • nucleus
Biological Process:	• transcription • mRNA processing • RNA splicing • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004882 (mRNA)
NP_004873 (protein)

XM_989689 (mRNA)
XP_994783 (protein)

Location

Chr 2: 174.92 - 174.97 Mb

Chr 2: 73.08 - 73.11 Mb

Pubmed search

[1]

[2]

CBF1 interacting corepressor, also known as CIR, is a human gene.^[1]

[edit] References

^ Entrez Gene: CIR CBF1 interacting corepressor.

[edit] Further reading

DuBridge RB, Tang P, Hsia HC, et al. (1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.". Mol. Cell. Biol. 7 (1): 379-87. PMID 3031469.
Hsieh JJ, Zhou S, Chen L, et al. (1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 23-8. PMID 9874765.
Zhou S, Fujimuro M, Hsieh JJ, et al. (2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters.". J. Virol. 74 (4): 1939-47. PMID 10644367.
Krithivas A, Young DB, Liao G, et al. (2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells.". J. Virol. 74 (20): 9637-45. PMID 11000236.
Zhang J, Chen H, Weinmaster G, Hayward SD (2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC.". J. Virol. 75 (6): 2946-56. doi:10.1128/JVI.75.6.2946-2956.2001. PMID 11222720.
Zhou S, Hayward SD (2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.". Mol. Cell. Biol. 21 (18): 6222-32. PMID 11509665.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing.". Exp. Cell Res. 303 (2): 375-87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.