Ciliate telomerase RNA

Ciliate telomerase RNA

Type:	Gene;
2° structure:	Published; PubMed; PubMed, Moxon SJ
Seed alignment:	McCormick-Graham and Romero, PubMed; Griffiths-Jones SR, Moxon SJ
Avg length:	179.0 nucleotides
Avg identity:	52%

Telomerase is a ribonucleoprotein reverse transcriptase that synthesises telomeric DNA. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence.^[1]^[2]^[3]

[edit] References

^ McCormick-Graham, M; Romero DP (1995). "Ciliate telomerase RNA structural features". Nucleic Acids Res 23: 1091–1097. doi:10.1093/nar/23.7.1091. PMID 7739888.
^ Lingner, J; Hendrick LL, Cech TR (1994). "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template". Genes Dev 8: 1984–1998. doi:10.1101/gad.8.16.1984. PMID 7958872.
^ Theimer CA, Feigon J (2006). "Structure and function of telomerase RNA". Curr. Opin. Struct. Biol. 16 (3): 307–18. doi:10.1016/j.sbi.2006.05.005. PMID 16713250.