Ciliary neurotrophic factor receptor

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ciliary neurotrophic factor receptor
Identifiers
Symbol CNTFR
Entrez 1271
HUGO 2170
OMIM 118946
RefSeq NM_001842
UniProt P26992
Other data
Locus Chr. 9 p13

The ciliary neurotrophic factor receptor also known as CNTFR binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons.[1] This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.[2]

[edit] References

  1. ^ Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD (1991). "The receptor for ciliary neurotrophic factor". Science 253 (5015): 59–63. doi:10.1126/science.1648265. PMID 1648265. 
  2. ^ Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ (2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv 74 (2-3): 265–72. PMID 10812968. 

[edit] External links


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