CHUK

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Conserved helix-loop-helix ubiquitous kinase
Identifiers
Symbol(s)	CHUK; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
External IDs	OMIM: 600664 MGI: 99484 HomoloGene: 979
Gene ontology Molecular Function: • nucleotide binding • protein binding • ATP binding • IkappaB kinase activity • transferase activity Cellular Component: • nucleus • cytoplasm Biological Process: • morphogenesis of an epithelial sheet • immune response • I-kappaB phosphorylation • anatomical structure morphogenesis • osteoclast differentiation • odontogenesis (sensu Vertebrata)
Orthologs
	Human	Mouse
Entrez	1147	12675
Ensembl	n/a	ENSMUSG00000025199
Uniprot	n/a	A0AUV3
Refseq	NM_001278 (mRNA) NP_001269 (protein)	NM_007700 (mRNA) NP_031726 (protein)
Location	n/a	Chr 19: 44.13 - 44.16 Mb
Pubmed search	[1]	[2]

Conserved helix-loop-helix ubiquitous kinase, also known as CHUK, is a gene whose protein product is part of the IκB kinase complex.

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.^[1]

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