CHRNA6

From Wikipedia, the free encyclopedia

Cholinergic receptor, nicotinic, alpha 6

Identifiers

External IDs

OMIM: 606888 MGI: 106213 HomoloGene: 20888

Gene ontology
Molecular Function:	• nicotinic acetylcholine-activated cation-selective channel activity • ion channel activity • extracellular ligand-gated ion channel activity • acetylcholine receptor activity
Cellular Component:	• nicotinic acetylcholine-gated receptor-channel complex • integral to membrane • postsynaptic membrane
Biological Process:	• ion transport • signal transduction • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004198 (mRNA)
NP_004189 (protein)

NM_021369 (mRNA)
NP_067344 (protein)

Location

Chr 8: 42.73 - 42.74 Mb

Chr 8: 28.87 - 28.88 Mb

Pubmed search

[1]

[2]

Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6.

[edit] Further reading

Zeiger JS, Haberstick BC, Schlaepfer I, et al. (2008). "The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.". Hum. Mol. Genet. 17 (5): 724-34. doi:10.1093/hmg/ddm344. PMID 18055561.
Shi J, Hattori E, Zou H, et al. (2007). "No evidence for association between 19 cholinergic genes and bipolar disorder.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (6): 715-23. doi:10.1002/ajmg.b.30417. PMID 17373692.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Keiger CJ, Case LD, Kendal-Reed M, et al. (2003). "Nicotinic cholinergic receptor expression in the human nasal mucosa.". Ann. Otol. Rhinol. Laryngol. 112 (1): 77-84. PMID 12537063.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ebihara M, Ohba H, Ohno SI, Yoshikawa T (2003). "Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression.". Gene 298 (1): 101-8. PMID 12406580.
Graham A, Court JA, Martin-Ruiz CM, et al. (2002). "Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum.". Neuroscience 113 (3): 493-507. PMID 12150770.
Le Novère N, Zoli M, Changeux JP (1997). "Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain.". Eur. J. Neurosci. 8 (11): 2428-39. PMID 8950106.
Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217-28. doi:10.1007/BF02736842. PMID 8906617.