Talk:Cholecalciferol
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[edit] SMILES Notation
The SMILES Notation that is on the page now does not match the picture, so I'm going to change it to match (the picture is right, I checked on the EPA website).
Here is what it is now:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(CCC[C@]12C)=C/C=C3/C[C@@H](O)CCC3=C
And here's what it actually is:
CC(C)CCC[C@@H](C)[C@H]1CCC2C(\CCCC12C)=C\C=C3\C[C@@H](O)CCC3=C
Sbrools (talk . contribs) 17:29, 6 May 2007 (UTC)
[edit] Clinical relevance
I haven't the time now, but this article desperately needs some clinical relevance. Cholecalciferol's clinical implications are very significant, with relation to Calcium absorption in the gut and renal osteodystrophy. 81.179.117.49 10:50, 17 June 2007 (UTC)
On a similar note, I thought that the following would be relevant;
The ratio of total 25OHD3 and 1,25(OH)2D3 to plasma DBP, rather than total circulating vitamin D metabolites, may provide a more useful index of biological activity. Further studies are required to substantiate this hypothesis. http://www.ncbi.nlm.nih.gov/pubmed/16339300?ordinalpos=33&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
I haven't been able to find any controlled studies that shows D3 supplementation counteracts bone loss in 25 D3 deficient individuals superior to calcium alone. Likewise, it's anti-cancer effects only appear in short term trials and are consistant with other immunosuppressives such as prednisone in this regard.
CONCLUSIONS: Kidney-transplant recipients receiving modern immunosuppressive regimens with low doses of corticosteroids experience only minimal loss of BMD during the first posttransplant year. Cholecalciferol supplementation did not prevent posttransplant bone loss http://www.ncbi.nlm.nih.gov/pubmed/15714177?ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
CONCLUSIONS: In this carefully controlled study calcium plus vitamin D3 supplements only had minor influences of uncertain significance on the calcium balance in healthy, calcium and vitamin D sufficient early postmenopausal women.
More succinctly, http://bacteriality.com/2007/09/15/vitamind/ http://trevormarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf —Preceding unsigned comment added by 63.166.226.83 (talk) 18:39, 4 June 2008 (UTC)
—Preceding unsigned comment added by Wiserd911 (talk • contribs) 04:28, 2 June 2008 (UTC)
--Ryan Wise (talk) 04:09, 2 June 2008 (UTC)
[edit] Overdose
While the main Vitamin D article notes the potential for oversupplementation, a single sentence in this article is probably merited as well, just to be on the safe side. (24.147.80.106 15:07, 26 June 2007 (UTC))
[edit] So, what's it do?
Yes, what is it good for?
TIA,
--Jerome Potts 08:01, 23 September 2007 (UTC)
Supplementation doesn't seem to increase bone density
In healthy individuals it activates the Vitamin D receptor, which serves an immune function. It is also immunosuppressive. (presumably, after you're out in the sun, your body needs some time to repair itself.)
For more info; http://bacteriality.com/2007/09/15/vitamind/
http://trevormarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf --Ryan Wise (talk) 18:42, 4 June 2008 (UTC)
[edit] Vegan D3
VEGAN D3...Hi there. If my comments are not appropriate please forgive. I've never posted on Widipedia until now.
I've been searching for D3 that does NOT come from fish oil. While not technically vegan, I have found D3 made from lanolin. The vitamin shelves are VERY confusing because most all products say their D3 comes from cholecalciferol. Vitamin consultants say all D3 is from fish oil. However, I contacted the maker of the D3 I'm taking and they assure me the cholecalciferolin their product comes from lanolin.
- That's quite plausible. You can actually extract D3 from the fat from sheep wool: D3 is formed when sunlight irradiates certain types of fat, including lanolin. As for saying the D3 "comes from" cholecalciferol: that's actually a form of D3, and doesn't give you any information on the source. It could be from fish liver or irradiated cholesterol (the kind that your body makes naturally). --Slashme (talk) 05:20, 21 January 2008 (UTC)
[edit] pig brains?
Does any one know about D3 coming from pig brains? Is lanolin the only source? 24.152.217.54 (talk) 14:54, 6 February 2008 (UTC)
