Chorismate lyase

From Wikipedia, the free encyclopedia

In enzymology, a chorismate lyase (EC 4.1.3.40) is an enzyme that catalyzes the chemical reaction

chorismate 4-hydroxybenzoate + pyruvate

Hence, this enzyme has one substrate, chorismate, and two products, 4-hydroxybenzoate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is chorismate pyruvate-lyase (4-hydroxybenzoate-forming). Other names in common use include CL, CPL, and UbiC. This enzyme participates in ubiquinone biosynthesis.

[edit] References

• IUBMB entry for 4.1.3.40
• BRENDA references for 4.1.3.40 (Recommended.)
• PubMed references for 4.1.3.40
• PubMed Central references for 4.1.3.40
• Google Scholar references for 4.1.3.40
• Nichols BP, Green JM (1992). "Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase". J. Bacteriol. 174: 5309–16. PMID 1644758. 
• Siebert M, Severin K, Heide L (Pt 4). "Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase". Microbiology. 140: 897–904. PMID 8012607. 
• Meganathan R (2001). "Ubiquinone biosynthesis in microorganisms". FEMS. Microbiol. Lett. 203: 131–9. doi:10.1111/j.1574-6968.2001.tb10831.x. PMID 11583838. 

[edit] External links

The CAS registry number for this enzyme class is 157482-18-3.

• IUBMB entry for 4.1.3.40

• KEGG entry for 4.1.3.40

• BRENDA entry for 4.1.3.40

• NiceZyme view of 4.1.3.40

• EC2PDB: PDB structures for 4.1.3.40

• PRIAM entry for 4.1.3.40

• PUMA2 entry for 4.1.3.40

• IntEnz: Integrated Enzyme entry for 4.1.3.40

• MetaCyc entry for 4.1.3.40

• Atomic-resolution structures of enzymes belonging to this class