Chondroitin 4-sulfotransferase

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In enzymology, a chondroitin 4-sulfotransferase (EC 2.8.2.5) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + chondroitin $\rightleftharpoons$ adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and chondroitin 4'-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase. This enzyme is also called chondroitin sulfotransferase. This enzyme participates in 3 metabolic pathways: chondroitin sulfate biosynthesis, sulfur metabolism, and the biosynthesis of glycan structures.

[edit] References

IUBMB entry for 2.8.2.5
BRENDA references for 2.8.2.5 (Recommended.)
PubMed references for 2.8.2.5
PubMed Central references for 2.8.2.5
Google Scholar references for 2.8.2.5
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Nakanishi Y, Otsu K, Suzuki S (1983). "Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine". FEBS. Lett. 151: 15–8. doi:10.1016/0014-5793(83)80332-9. PMID 6130977.
Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S (1981). "A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate". J. Biol. Chem. 256: 5443–9. PMID 6787041.
Suzuki S and Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. I Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides". J. Biol. Chem. 235: 257–266.
Suzuki S and Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. II Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors". J. Biol. Chem. 235: 267–273.
Suzuki S and Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. III Mechanism of sulfation of chondroitin and chondroitin sulfate A". J. Biol. Chem. 235: 274–276.