Chondro-6-sulfatase

From Wikipedia, the free encyclopedia

In enzymology, a chondro-6-sulfatase (EC 3.1.6.10) is an enzyme that catalyzes the chemical reaction

4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 6-sulfate + H₂O 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate

The 3 substrates of this enzyme are 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine, 6-sulfate, and H₂O, whereas its two products are 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-su lfate 6-sulfohydrolase.

[edit] References

• IUBMB entry for 3.1.6.10
• BRENDA references for 3.1.6.10 (Recommended.)
• PubMed references for 3.1.6.10
• PubMed Central references for 3.1.6.10
• Google Scholar references for 3.1.6.10
• Yamagata T, Saito H, Habuchi O, Suzuki S (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243: 1523–35. PMID 5647268. 

[edit] External links

The CAS registry number for this enzyme class is 9045-76-5.

• IUBMB entry for 3.1.6.10

• KEGG entry for 3.1.6.10

• BRENDA entry for 3.1.6.10

• NiceZyme view of 3.1.6.10

• EC2PDB: PDB structures for 3.1.6.10

• PRIAM entry for 3.1.6.10

• PUMA2 entry for 3.1.6.10

• IntEnz: Integrated Enzyme entry for 3.1.6.10

• MetaCyc entry for 3.1.6.10

• Atomic-resolution structures of enzymes belonging to this class