CHODL

From Wikipedia, the free encyclopedia

Chondrolectin

Identifiers

CHODL; C21orf68; FLJ12627; MT75; PRED12

External IDs

OMIM: 607247 MGI: 2179069 HomoloGene: 11795

Gene ontology
Molecular Function:	• sugar binding • hyaluronic acid binding
Cellular Component:	• membrane • integral to membrane • perinuclear region of cytoplasm
Biological Process:	• muscle development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024944 (mRNA)
NP_079220 (protein)

NM_139134 (mRNA)
NP_624360 (protein)

Location

Chr 21: 18.54 - 18.56 Mb

Chr 16: 78.81 - 78.83 Mb

Pubmed search

[1]

[2]

Chondrolectin, also known as CHODL, is a human gene.^[1]

This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region.^[1]

[edit] References

^ ^a ^b Entrez Gene: CHODL chondrolectin.

[edit] Further reading

Claessens A, Van de Vijver K, Van Bockstaele DR, et al. (2007). "Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin.". Cell Biol. Int. 31 (11): 1323-30. doi:10.1016/j.cellbi.2007.05.014. PMID 17606388.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Weng L, Van Bockstaele DR, Wauters J, et al. (2003). "A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation.". J. Biol. Chem. 278 (21): 19164-70. doi:10.1074/jbc.M300653200. PMID 12621022.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Weng L, Smits P, Wauters J, Merregaert J (2003). "Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins.". Genomics 80 (1): 62-70. PMID 12079284.
Reymond A, Friedli M, Henrichsen CN, et al. (2002). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.". Genomics 78 (1-2): 46-54. doi:10.1006/geno.2001.6640. PMID 11707072.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.