Talk:Chiral ligand
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[edit] Need for a ligand to be enantiopure is questionable
Hi, I believe there is a conceptual mistake on this page: I do not think that a chiral ligand needs to be enantiopure. Noyori introduced the concept of chiral amplification in asymmetric synthesis to describe the situation in which a ligand with a low ee induces a quite large ee in the product of the ligand-catalyszed reaction. This is one of the few but real cases of "non-linear effects" in asymmetric synthesis, the non-linearity indicating in this case that the ee of the product is not proportional to the ee of the ligand. His concept was developed on the basis of the DAIB-catalyzed addition of diorganozinc reagents on aldehydes, which is a typical case of ligand-accelerated catalysis. See Enantioselective Addition of Organometallic Reagents to Carbonyl Compounds: Chirality Transfer, Multiplication, and Amplification. R. Noyori and M. Kitamura, Angew. Chem., Int. Ed. Engl., 30, 49 (1991). I'm working on a new page on this topic, but would be interested on your feedback!
