CHI3L1

From Wikipedia, the free encyclopedia

Chitinase 3-like 1 (cartilage glycoprotein-39)

PDB rendering based on 1hjv.

Available structures: 1hjv, 1hjw, 1hjx, 1nwr, 1nws, 1nwt, 1nwu

Identifiers

Symbol(s)

CHI3L1; GP39; HC-gp39; HCGP-3P; YKL40; YYL-40

External IDs

OMIM: 601525 MGI: 1340899 HomoloGene: 55569

Gene ontology
Molecular Function:	• catalytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • chitinase activity • extracellular matrix structural constituent • sugar binding • cation binding
Cellular Component:	• proteinaceous extracellular matrix • extracellular space
Biological Process:	• carbohydrate metabolic process • chitin catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001276 (mRNA)
NP_001267 (protein)

NM_007695 (mRNA)
NP_031721 (protein)

Location

Chr 1: 201.41 - 201.42 Mb

Chr 1: 136 - 136.01 Mb

Pubmed search

[1]

[2]

Chitinase 3-like 1 (cartilage glycoprotein-39), also known as CHI3L1, is a human gene.^[1] It has been implicated in asthma, with the discovery of an allele that doubles the risk.^[2]

[edit] References

[edit] Further reading

Rathcke CN, Vestergaard H (2007). "YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis.". Inflamm. Res. 55 (6): 221–7. doi:10.1007/s00011-006-0076-y. PMID 16955240.
Nyirkos P, Golds EE (1990). "Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period.". Biochem. J. 269 (1): 265–8. PMID 2375755.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hakala BE, White C, Recklies AD (1994). "Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.". J. Biol. Chem. 268 (34): 25803–10. PMID 8245017.
Rehli M, Krause SW, Andreesen R (1997). "Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.". Genomics 43 (2): 221–5. doi:10.1006/geno.1997.4778. PMID 9244440.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kirkpatrick RB, Emery JG, Connor JR, et al. (1998). "Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages.". Exp. Cell Res. 237 (1): 46–54. doi:10.1006/excr.1997.3764. PMID 9417865.
Renkema GH, Boot RG, Au FL, et al. (1998). "Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.". Eur. J. Biochem. 251 (1-2): 504–9. PMID 9492324.
Johansen JS, Stoltenberg M, Hansen M, et al. (1999). "Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity.". Rheumatology (Oxford) 38 (7): 618–26. PMID 10461474.
Nordenbaek C, Johansen JS, Junker P, et al. (1999). "YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization.". J. Infect. Dis. 180 (5): 1722–6. PMID 10515841.
Connor JR, Dodds RA, Emery JG, et al. (2000). "Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization.". Osteoarthr. Cartil. 8 (2): 87–95. doi:10.1053/joca.1999.0276. PMID 10772238.
Østergaard C, Johansen JS, Benfield T, et al. (2002). "YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis.". Clin. Diagn. Lab. Immunol. 9 (3): 598–604. PMID 11986266.
Kronborg G, Ostergaard C, Weis N, et al. (2003). "Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease.". Scand. J. Infect. Dis. 34 (5): 323–6. PMID 12069012.
Recklies AD, White C, Ling H (2002). "The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways.". Biochem. J. 365 (Pt 1): 119–26. doi:10.1042/BJ20020075. PMID 12071845.
Cintin C, Johansen JS, Christensen IJ, et al. (2002). "High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival.". Cancer 95 (2): 267–74. doi:10.1002/cncr.10644. PMID 12124825.
Steck E, Breit S, Breusch SJ, et al. (2003). "Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage.". Biochem. Biophys. Res. Commun. 299 (1): 109–15. PMID 12435396.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Steenbakkers PG, Baeten D, Rovers E, et al. (2003). "Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies.". J. Immunol. 170 (11): 5719–27. PMID 12759455.
Houston DR, Recklies AD, Krupa JC, van Aalten DM (2003). "Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes.". J. Biol. Chem. 278 (32): 30206–12. doi:10.1074/jbc.M303371200. PMID 12775711.
Nishikawa KC, Millis AJ (2003). "gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells.". Exp. Cell Res. 287 (1): 79–87. PMID 12799184.