CHD3

From Wikipedia, the free encyclopedia

Chromodomain helicase DNA binding protein 3

Identifiers

CHD3; Mi-2a; Mi2-ALPHA; ZFH

External IDs

OMIM: 602120 MGI: 1344395 HomoloGene: 62693

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • ATP-dependent DNA helicase activity • protein binding • ATP binding • ATP-dependent helicase activity • zinc ion binding • hydrolase activity • metal ion binding
Cellular Component:	• chromatin • nucleus
Biological Process:	• chromatin assembly or disassembly • transcription • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • chromosome organization and biogenesis (sensu Eukaryota) • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001005271 (mRNA)
NP_001005271 (protein)

XM_484041 (mRNA)
XP_484041 (protein)

Location

Chr 17: 7.73 - 7.76 Mb

Chr 11: 69.16 - 69.19 Mb

Pubmed search

[1]

[2]

Chromodomain helicase DNA binding protein 3, also known as CHD3, is a human gene.^[1]

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: CHD3 chromodomain helicase DNA binding protein 3.

[edit] Further reading

Bowen NJ, Fujita N, Kajita M, Wade PA (2004). "Mi-2/NuRD: multiple complexes for many purposes.". Biochim. Biophys. Acta 1677 (1-3): 52-7. doi:10.1016/j.bbaexp.2003.10.010. PMID 15020045.
Gieser L, Swaroop A (1992). "Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigment epithelium library.". Genomics 13 (3): 873-6. PMID 1639417.
Ge Q, Nilasena DS, O'Brien CA, et al. (1995). "Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.". J. Clin. Invest. 96 (4): 1730-7. PMID 7560064.
Seelig HP, Moosbrugger I, Ehrfeld H, et al. (1995). "The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.". Arthritis Rheum. 38 (10): 1389-99. PMID 7575689.
Seelig HP, Renz M, Targoff IN, et al. (1996). "Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.". Arthritis Rheum. 39 (10): 1769-71. PMID 8843877.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Woodage T, Basrai MA, Baxevanis AD, et al. (1997). "Characterization of the CHD family of proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11472-7. PMID 9326634.
Aubry F, Mattéi MG, Galibert F (1998). "Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family.". Eur. J. Biochem. 254 (3): 558-64. PMID 9688266.
Tong JK, Hassig CA, Schnitzler GR, et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.". Nature 395 (6705): 917-21. doi:10.1038/27699. PMID 9804427.
Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain.". Hum. Genet. 103 (6): 666-73. PMID 9921901.
Kim J, Sif S, Jones B, et al. (1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.". Immunity 10 (3): 345-55. PMID 10204490.
Wade PA, Gegonne A, Jones PL, et al. (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.". Nat. Genet. 23 (1): 62-6. doi:10.1038/12664. PMID 10471500.
Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53.". Genomics 63 (1): 60-8. doi:10.1006/geno.1999.6062. PMID 10662545.
Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.". J. Biol. Chem. 275 (46): 36316-23. doi:10.1074/jbc.M004293200. PMID 10961991.
Schultz DC, Friedman JR, Rauscher FJ (2001). "Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.". Genes Dev. 15 (4): 428-43. doi:10.1101/gad.869501. PMID 11230151.
Yasui D, Miyano M, Cai S, et al. (2002). "SATB1 targets chromatin remodelling to regulate genes over long distances.". Nature 419 (6907): 641-5. doi:10.1038/nature01084. PMID 12374985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lemos TA, Passos DO, Nery FC, Kobarg J (2003). "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.". FEBS Lett. 533 (1-3): 14-20. PMID 12505151.
Fujita N, Jaye DL, Kajita M, et al. (2003). "MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.". Cell 113 (2): 207-19. PMID 12705869.
Lee BH, Yoshimatsu K, Maeda A, et al. (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.". Virus Res. 98 (1): 83-91. PMID 14609633.