CHD1

From Wikipedia, the free encyclopedia

Chromodomain helicase DNA binding protein 1

PDB rendering based on 2b2t.

Available structures: 2b2t, 2b2u, 2b2v, 2b2w, 2b2y

Identifiers

Symbol(s)

CHD1; DKFZp686E2337

External IDs

OMIM: 602118 MGI: 88393 HomoloGene: 86052

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • ATP-dependent DNA helicase activity • helicase activity • ATP binding • hydrolase activity
Cellular Component:	• chromatin • nucleus
Biological Process:	• chromatin assembly or disassembly • regulation of transcription from RNA polymerase II promoter • chromosome organization and biogenesis (sensu Eukaryota)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001270 (mRNA)
NP_001261 (protein)

NM_007690 (mRNA)
NP_031716 (protein)

Location

Chr 5: 98.22 - 98.29 Mb

Chr 17: 15.41 - 15.48 Mb

Pubmed search

[1]

[2]

Chromodomain helicase DNA binding protein 1, also known as CHD1, is a human gene.^[1]

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.^[1]

[edit] References

^ ^a ^b Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1.

[edit] Further reading

Stokes DG, Perry RP (1995). "DNA-binding and chromatin localization properties of CHD1.". Mol. Cell. Biol. 15 (5): 2745–53. PMID 7739555.
Delmas V, Stokes DG, Perry RP (1993). "A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain.". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2414–8. PMID 8460153.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Woodage T, Basrai MA, Baxevanis AD, et al. (1997). "Characterization of the CHD family of proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11472–7. PMID 9326634.
Kelley DE, Stokes DG, Perry RP (1999). "CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin.". Chromosoma 108 (1): 10–25. PMID 10199952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMID 12522270.
Tai HH, Geisterfer M, Bell JC, et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.". Biochem. Biophys. Res. Commun. 308 (1): 170–6. PMID 12890497.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Sims RJ, Chen CF, Santos-Rosa H, et al. (2006). "Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.". J. Biol. Chem. 280 (51): 41789–92. doi:10.1074/jbc.C500395200. PMID 16263726.
Flanagan JF, Mi LZ, Chruszcz M, et al. (2006). "Double chromodomains cooperate to recognize the methylated histone H3 tail.". Nature 438 (7071): 1181–5. doi:10.1038/nature04290. PMID 16372014.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Okuda M, Horikoshi M, Nishimura Y (2007). "Structural polymorphism of chromodomains in Chd1.". J. Mol. Biol. 365 (4): 1047–62. doi:10.1016/j.jmb.2006.10.039. PMID 17098252.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.