CFLAR

CASP8 and FADD-like apoptosis regulator

Identifiers

CFLAR; CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLIP; I-FLICE; MRIT; USURPIN; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS

External IDs

Gene ontology
Molecular Function:	• signal transducer activity • protein binding • caspase activity
Biological Process:	• proteolysis • anti-apoptosis • induction of apoptosis by extracellular signals • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003879 (mRNA)
NP_003870 (protein)

NM_009805 (mRNA)
NP_033935 (protein)

Location

Pubmed search

CASP8 and FADD-like apoptosis regulator, also known as CFLAR, is a human gene.

[edit] Further reading

Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926: 52–63. PMID 11193041.
Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.". Expert Opin. Ther. Targets 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226.