CETN3

From Wikipedia, the free encyclopedia

Centrin, EF-hand protein, 3 (CDC31 homolog, yeast)

Identifiers

CETN3; CEN3; MGC12502; MGC138245

External IDs

OMIM: 602907 MGI: 1097706 HomoloGene: 74521

Gene ontology
Molecular Function:	• calcium ion binding
Cellular Component:	• centriole
Biological Process:	• cell cycle • mitosis • centrosome cycle • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004365 (mRNA)
NP_004356 (protein)

NM_007684 (mRNA)
NP_031710 (protein)

Location

Chr 5: 89.73 - 89.74 Mb

Chr 13: 82.26 - 82.27 Mb

Pubmed search

[1]

[2]

Centrin, EF-hand protein, 3 (CDC31 homolog, yeast), also known as CETN3, is a human gene.^[1]

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.^[1]

[edit] References

^ ^a ^b Entrez Gene: CETN3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast).

[edit] Further reading

Salisbury JL (2004). "Centrosomes: Sfi1p and centrin unravel a structural riddle.". Curr. Biol. 14 (1): R27–9. PMID 14711432.
Wiech H, Geier BM, Paschke T, et al. (1996). "Characterization of green alga, yeast, and human centrins. Specific subdomain features determine functional diversity.". J. Biol. Chem. 271 (37): 22453–61. PMID 8798410.
Paoletti A, Moudjou M, Paintrand M, et al. (1997). "Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles.". J. Cell. Sci. 109 ( Pt 13): 3089–102. PMID 9004043.
Middendorp S, Paoletti A, Schiebel E, Bornens M (1997). "Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9141–6. PMID 9256449.
LeDizet M, Beck JC, Finkbeiner WE (1999). "Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells.". Am. J. Physiol. 275 (6 Pt 1): L1145–56. PMID 9843852.
Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro.". J. Cell. Sci. 113 ( Pt 8): 1355–64. PMID 10725219.
Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Schiebel E, Bornens M (2004). "In search of a function for centrins.". Trends Cell Biol. 5 (5): 197–201. PMID 14731449.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Cox JA, Tirone F, Durussel I, et al. (2005). "Calcium and magnesium binding to human centrin 3 and interaction with target peptides.". Biochemistry 44 (3): 840–50. doi:10.1021/bi048294e. PMID 15654740.
Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.". Traffic 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.