CETN2

From Wikipedia, the free encyclopedia

Centrin, EF-hand protein, 2

PDB rendering based on 1m39.

Available structures: 1m39, 1zmz, 2a4j, 2ggm

Identifiers

Symbol(s)

CETN2; CALT; CEN2

External IDs

OMIM: 300006 MGI: 1347085 HomoloGene: 55813

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• intracellular • centriole
Biological Process:	• cell cycle • mitosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004344 (mRNA)
NP_004335 (protein)

NM_019405 (mRNA)
NP_062278 (protein)

Location

Chr X: 151.75 - 151.75 Mb

Chr X: 69.17 - 69.17 Mb

Pubmed search

[1]

[2]

Centrin, EF-hand protein, 2, also known as CETN2, is a human gene.^[1]

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.^[1]

[edit] References

^ ^a ^b Entrez Gene: CETN2 centrin, EF-hand protein, 2.

[edit] Further reading

Tanaka T, Okui K, Nakamura Y (1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization.". Genomics 24 (3): 609–10. PMID 7713520.
Lee VD, Huang B (1994). "Molecular cloning and centrosomal localization of human caltractin.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11039–43. PMID 8248209.
Chatterjee A, Tanaka T, Parrish JE, Herman GE (1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions.". Mamm. Genome 6 (11): 802–4. PMID 8597638.
Wolfrum U, Salisbury JL (1998). "Expression of centrin isoforms in the mammalian retina.". Exp. Cell Res. 242 (1): 10–7. doi:10.1006/excr.1998.4038. PMID 9665797.
Durussel I, Blouquit Y, Middendorp S, et al. (2000). "Cation- and peptide-binding properties of human centrin 2.". FEBS Lett. 472 (2-3): 208–12. PMID 10788612.
Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.". Genome Res. 10 (6): 758–75. PMID 10854409.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Araki M, Masutani C, Takemura M, et al. (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.". J. Biol. Chem. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. PMID 11279143.
Salisbury JL, Suino KM, Busby R, Springett M (2003). "Centrin-2 is required for centriole duplication in mammalian cells.". Curr. Biol. 12 (15): 1287–92. PMID 12176356.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matei E, Miron S, Blouquit Y, et al. (2003). "C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain.". Biochemistry 42 (6): 1439–50. doi:10.1021/bi0269714. PMID 12578356.
Gavet O, Alvarez C, Gaspar P, Bornens M (2004). "Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells.". Mol. Biol. Cell 14 (5): 1818–34. doi:10.1091/mbc.E02-11-0709. PMID 12802058.
Popescu A, Miron S, Blouquit Y, et al. (2003). "Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin.". J. Biol. Chem. 278 (41): 40252–61. doi:10.1074/jbc.M302546200. PMID 12890685.
Kilmartin JV (2003). "Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication.". J. Cell Biol. 162 (7): 1211–21. doi:10.1083/jcb.200307064. PMID 14504268.
Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.". Mol. Biol. Cell 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMID 14767062.
Tourbez M, Firanescu C, Yang A, et al. (2005). "Calcium-dependent self-assembly of human centrin 2.". J. Biol. Chem. 279 (46): 47672–80. doi:10.1074/jbc.M404996200. PMID 15356003.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Nishi R, Okuda Y, Watanabe E, et al. (2005). "Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.". Mol. Cell. Biol. 25 (13): 5664–74. doi:10.1128/MCB.25.13.5664-5674.2005. PMID 15964821.