CES3 (gene)

From Wikipedia, the free encyclopedia

Carboxylesterase 3 (brain)

Identifiers

CES3; Br3; ES31; FLJ21736

External IDs

Gene ontology
Molecular Function:	• carboxylesterase activity • hydrolase activity

Orthologs

Human

Mouse

Entrez

23491

n/a

Refseq

NM_024922 (mRNA)
NP_079198 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Carboxylesterase 3 (brain), also known as CES3, is a human gene.^[1]

Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system.^[1]

[edit] References

^ ^a ^b Entrez Gene: CES3 carboxylesterase 3 (brain).

[edit] Further reading

Lee CV, Hymowitz SG, Wallweber HJ, et al. (2006). "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.". Blood 108 (9): 3103-11. doi:10.1182/blood-2006-03-011031. PMID 16840730.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346-58. doi:10.1002/pmic.200300770. PMID 15188402.
Sanghani SP, Quinney SK, Fredenburg TB, et al. (2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.". Drug Metab. Dispos. 32 (5): 505-11. doi:10.1124/dmd.32.5.505. PMID 15100172.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Sanghani SP, Quinney SK, Fredenburg TB, et al. (2004). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.". Clin. Cancer Res. 9 (13): 4983-91. PMID 14581373.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304-51. doi:10.1126/science.1058040. PMID 11181995.
Mori M, Hosokawa M, Ogasawara Y, et al. (1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase.". FEBS Lett. 458 (1): 17-22. PMID 10518925.
Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver.". Biochim. Biophys. Acta 1174 (1): 72-4. PMID 7916639.