Ceramide kinase

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In enzymology, a ceramide kinase (EC 2.7.1.138) is an enzyme that catalyzes the chemical reaction

ATP + ceramide ADP + ceramide 1-phosphate

Thus, the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:ceramide 1-phosphotransferase. This enzyme is also called acylsphingosine kinase. This enzyme participates in sphingolipid metabolism.

[edit] References

• IUBMB entry for 2.7.1.138
• BRENDA references for 2.7.1.138 (Recommended.)
• PubMed references for 2.7.1.138
• PubMed Central references for 2.7.1.138
• Google Scholar references for 2.7.1.138
• Bajjalieh SM, Martin TF, Floor E (1989). "Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles". J. Biol. Chem. 264: 14354–60. PMID 2547795. 

[edit] External links

The CAS registry number for this enzyme class is 123175-68-8.

• IUBMB entry for 2.7.1.138

• KEGG entry for 2.7.1.138

• BRENDA entry for 2.7.1.138

• NiceZyme view of 2.7.1.138

• EC2PDB: PDB structures for 2.7.1.138

• PRIAM entry for 2.7.1.138

• PUMA2 entry for 2.7.1.138

• IntEnz: Integrated Enzyme entry for 2.7.1.138

• MetaCyc entry for 2.7.1.138

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0001729: ceramide kinase

• AMIGO entry for GO code 0001729: ceramide kinase