Ceramide cholinephosphotransferase

From Wikipedia, the free encyclopedia

In enzymology, a ceramide cholinephosphotransferase (EC 2.7.8.3) is an enzyme that catalyzes the chemical reaction

CDP-choline + N-acylsphingosine CMP + sphingomyelin

Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism.

[edit] References

• IUBMB entry for 2.7.8.3
• BRENDA references for 2.7.8.3 (Recommended.)
• PubMed references for 2.7.8.3
• PubMed Central references for 2.7.8.3
• Google Scholar references for 2.7.8.3
• Kennedy EP (1962). "Phosphorylcholine-glyceride transferase". Methods Enzymol. 5: 484–486. 
• Sribney M and Kennedy EP (1958). "The enzymatic synthesis of sphingomyelin". J. Biol. Chem. 233: 1315–1322. 

[edit] External links

The CAS registry number for this enzyme class is 9026-14-6.

• IUBMB entry for 2.7.8.3

• KEGG entry for 2.7.8.3

• BRENDA entry for 2.7.8.3

• NiceZyme view of 2.7.8.3

• EC2PDB: PDB structures for 2.7.8.3

• PRIAM entry for 2.7.8.3

• PUMA2 entry for 2.7.8.3

• IntEnz: Integrated Enzyme entry for 2.7.8.3

• MetaCyc entry for 2.7.8.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047493: ceramide cholinephosphotransferase

• AMIGO entry for GO code 0047493: ceramide cholinephosphotransferase