Cephalosporin-C transaminase

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In enzymology, a cephalosporin-C transaminase (EC 2.6.1.74) is an enzyme that catalyzes the chemical reaction

(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate cephalosporin C + 2-oxoglutarate

Thus, the two substrates of this enzyme are (7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate and D-glutamate, whereas its two products are cephalosporin C and 2-oxoglutarate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is cephalosporin-C:2-oxoglutarate aminotransferase. Other names in common use include cephalosporin C aminotransferase, and L-alanine:cephalosporin-C aminotransferase. This enzyme participates in penicillin and cephalosporin biosynthesis.

[edit] References

• IUBMB entry for 2.6.1.74
• BRENDA references for 2.6.1.74 (Recommended.)
• PubMed references for 2.6.1.74
• PubMed Central references for 2.6.1.74
• Google Scholar references for 2.6.1.74
• Aretz W, Sauber K (1988). "Novel D-amino acid transaminase". Ann. N. Y. Acad. Sci. 542: 366–70. PMID 3228235. 

[edit] External links

The CAS registry number for this enzyme class is 122096-91-7.

• IUBMB entry for 2.6.1.74

• KEGG entry for 2.6.1.74

• BRENDA entry for 2.6.1.74

• NiceZyme view of 2.6.1.74

• EC2PDB: PDB structures for 2.6.1.74

• PRIAM entry for 2.6.1.74

• PUMA2 entry for 2.6.1.74

• IntEnz: Integrated Enzyme entry for 2.6.1.74

• MetaCyc entry for 2.6.1.74

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047740: cephalosporin-C transaminase

• AMIGO entry for GO code 0047740: cephalosporin-C transaminase