Cephalosporin-C deacetylase
From Wikipedia, the free encyclopedia
In enzymology, a cephalosporin-C deacetylase (EC 3.1.1.41) is an enzyme that catalyzes the chemical reaction
- cephalosporin C + H2O
deacetylcephalosporin C + acetate
Thus, the two substrates of this enzyme are cephalosporin C and H2O, whereas its two products are deacetylcephalosporin C and acetate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cephalosporin-C acetylhydrolase. Other names in common use include cephalosporin C acetyl-hydrolase, cephalosporin C acetylase, cephalosporin acetylesterase, cephalosporin C acetylesterase, cephalosporin C acetyl-esterase, and cephalosporin C deacetylase. This enzyme participates in penicillin and cephalosporin biosynthesis.
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[edit] Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1L7A, 1ODS, 1ODT, and 1VLQ.
[edit] References
- IUBMB entry for 3.1.1.41
- BRENDA references for 3.1.1.41 (Recommended.)
- PubMed references for 3.1.1.41
- PubMed Central references for 3.1.1.41
- Google Scholar references for 3.1.1.41
- Fujisawa Y, Shirafugi H, Kida M, Nara K, Yoneda M, Kanzaki T (1973). "New findings on cephalosporin C biosynthesis". Nat. New. Biol. 246: 154–5. PMID 4519146.
[edit] External links
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- The CAS registry number for this enzyme class is 52227-71-1.
[edit] Gene Ontology (GO) codes
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