Cell therapy
From Wikipedia, the free encyclopedia
Cell therapy describes the process of introducing new cells into a tissue in order to treat a disease. Cell therapies often focus on the treatment of hereditary diseases, with or without the addition of gene therapy.
There are many potential forms of cell therapy:
- The transplantation of stem cells that are autologous (from the patient) or allogeneic (from another donor).
- The transplantation of mature, functional cells.
- The application of modified human cells that are used to produce a needed substance.
- The xenotransplantation of non-human cells that are used to produce a needed substance. For example, treating diabetic patients by introducing insulin-producing pig cells directly into their muscle.
- The transplantation of transdifferentiated cells derived from the patient's own differentiated cells. For example, the use of insulin producing beta cells transdifferentiated from isolated hepatocytes as a treatment for diabetes.
Increasingly, mesenchymal stem cells are being proposed as agents for cell-based therapies, due to their plasticity, established isolation procedures, and capacity for ex vivo expansion.
