Cell adhesion molecule 1

From Wikipedia, the free encyclopedia

Identifiers

CADM1; BL2; DKFZp686F1789; IGSF4; IGSF4A; MGC149785; MGC51880; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; synCAM1

External IDs

OMIM: 605686 MGI: 1889272 HomoloGene: 8641

Gene ontology
Molecular Function:	• receptor binding • protein C-terminus binding • PDZ domain binding • protein homodimerization activity
Cellular Component:	• plasma membrane • intercellular junction • basolateral plasma membrane
Biological Process:	• T cell mediated cytotoxicity • homophilic cell adhesion • heterophilic cell adhesion • cell recognition • calcium-independent cell-cell adhesion • susceptibility to natural killer cell mediated cytotoxicity • positive regulation of cytokine secretion • activated T cell proliferation • detection of stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014333 (mRNA)
NP_055148 (protein)

NM_001025600 (mRNA)
NP_001020771 (protein)

Location

Chr 11: 114.55 - 114.88 Mb

Chr 9: 47.28 - 47.6 Mb

Pubmed search

[1]

[2]

Cell adhesion molecule 1, also known as CADM1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CADM1 cell adhesion molecule 1.

[edit] Further reading

Watabe K, Ito A, Koma YI, Kitamura Y (2004). "IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function.". Histol. Histopathol. 18 (4): 1321-9. PMID 12973698.
Gomyo H, Arai Y, Tanigami A, et al. (2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2.". Genomics 62 (2): 139-46. doi:10.1006/geno.1999.6001. PMID 10610705.
Kuramochi M, Fukuhara H, Nobukuni T, et al. (2001). "TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.". Nat. Genet. 27 (4): 427-30. doi:10.1038/86934. PMID 11279526.
Masuda M, Yageta M, Fukuhara H, et al. (2002). "The tumor suppressor protein TSLC1 is involved in cell-cell adhesion.". J. Biol. Chem. 277 (34): 31014-9. doi:10.1074/jbc.M203620200. PMID 12050160.
Fukuhara H, Kuramochi M, Fukami T, et al. (2003). "Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer.". Jpn. J. Cancer Res. 93 (6): 605-9. PMID 12079507.
Allinen M, Peri L, Kujala S, et al. (2002). "Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation.". Genes Chromosomes Cancer 34 (4): 384-9. doi:10.1002/gcc.10079. PMID 12112527.
Biederer T, Sara Y, Mozhayeva M, et al. (2002). "SynCAM, a synaptic adhesion molecule that drives synapse assembly.". Science 297 (5586): 1525-31. doi:10.1126/science.1072356. PMID 12202822.
Yageta M, Kuramochi M, Masuda M, et al. (2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer.". Cancer Res. 62 (18): 5129-33. PMID 12234973.
Jansen M, Fukushima N, Rosty C, et al. (2003). "Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs.". Cancer Biol. Ther. 1 (3): 293-6. PMID 12432281.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Honda T, Tamura G, Waki T, et al. (2003). "Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines.". Jpn. J. Cancer Res. 93 (8): 857-60. PMID 12716461.
Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.". J. Biol. Chem. 278 (37): 35421-7. doi:10.1074/jbc.M305387200. PMID 12826663.
Ito A, Okada M, Uchino K, et al. (2003). "Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma.". Lab. Invest. 83 (8): 1175-83. PMID 12920246.
Fukami T, Fukuhara H, Kuramochi M, et al. (2003). "Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.". Int. J. Cancer 107 (1): 53-9. doi:10.1002/ijc.11348. PMID 12925956.
Uchino K, Ito A, Wakayama T, et al. (2003). "Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung.". Cancer 98 (5): 1002-7. doi:10.1002/cncr.11599. PMID 12942568.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Fukuhara H, Masuda M, Yageta M, et al. (2003). "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.". Oncogene 22 (40): 6160-5. doi:10.1038/sj.onc.1206744. PMID 13679854.
Ito T, Shimada Y, Hashimoto Y, et al. (2003). "Involvement of TSLC1 in progression of esophageal squamous cell carcinoma.". Cancer Res. 63 (19): 6320-6. PMID 14559819.
Mao X, Seidlitz E, Ghosh K, et al. (2004). "The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.". Cancer Res. 63 (22): 7979-85. PMID 14633730.