CDP-diacylglycerol diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, a CDP-diacylglycerol diphosphatase (EC 3.6.1.26) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + H₂O CMP + phosphatidate

Thus, the two substrates of this enzyme are CDP-diacylglycerol and H₂O, whereas its two products are CMP and phosphatidate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is CDP-diacylglycerol phosphatidylhydrolase. Other names in common use include cytidine diphosphodiacylglycerol pyrophosphatase, and CDP diacylglycerol hydrolase. This enzyme participates in glycerophospholipid metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2POF.

[edit] References

• IUBMB entry for 3.6.1.26
• BRENDA references for 3.6.1.26 (Recommended.)
• PubMed references for 3.6.1.26
• PubMed Central references for 3.6.1.26
• Google Scholar references for 3.6.1.26
• Raetz CR, Hirschberg CB, Dowhan W, Wickner WT, Kennedy EP (1972). "A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride". J. Biol. Chem. 247: 2245–7. PMID 4335869. 

[edit] External links

The CAS registry number for this enzyme class is 62213-20-1.

• IUBMB entry for 3.6.1.26

• KEGG entry for 3.6.1.26

• BRENDA entry for 3.6.1.26

• NiceZyme view of 3.6.1.26

• EC2PDB: PDB structures for 3.6.1.26

• PRIAM entry for 3.6.1.26

• PUMA2 entry for 3.6.1.26

• IntEnz: Integrated Enzyme entry for 3.6.1.26

• MetaCyc entry for 3.6.1.26

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008715: CDP-diacylglycerol diphosphatase

• AMIGO entry for GO code 0008715: CDP-diacylglycerol diphosphatase