CDKN3

From Wikipedia, the free encyclopedia

Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)

PDB rendering based on 1fpz.

Available structures: 1fpz, 1fq1

Identifiers

Symbol(s)

CDKN3; CDI1; CIP2; FLJ25787; KAP; KAP1; MGC70625

External IDs

OMIM: 123832 MGI: 1919641 HomoloGene: 3805

Gene ontology
Molecular Function:	• phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • protein binding • protein tyrosine/serine/threonine phosphatase activity • hydrolase activity
Biological Process:	• regulation of cyclin-dependent protein kinase activity • G1/S transition of mitotic cell cycle • protein amino acid dephosphorylation • cell cycle • cell cycle arrest • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005192 (mRNA)
NP_005183 (protein)

XM_891957 (mRNA)
XP_897050 (protein)

Location

Chr 14: 53.93 - 53.96 Mb

Chr 14: 45.68 - 45.69 Mb

Pubmed search

[1]

[2]

Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase), also known as CDKN3, is a human gene.^[1]

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase).

[edit] Further reading

Poon RY, Hunter T (1995). "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin.". Science 270 (5233): 90-3. PMID 7569954.
Demetrick DJ, Matsumoto S, Hannon GJ, et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).". Cytogenet. Cell Genet. 69 (3-4): 190-2. PMID 7698009.
Hannon GJ, Casso D, Beach D (1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1731-5. PMID 8127873.
Gyuris J, Golemis E, Chertkov H, Brent R (1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.". Cell 75 (4): 791-803. PMID 8242750.
Harper JW, Adami GR, Wei N, et al. (1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.". Cell 75 (4): 805-16. PMID 8242751.
Sexl V, Diehl JA, Sherr CJ, et al. (1999). "A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2.". Oncogene 18 (3): 573-82. doi:10.1038/sj.onc.1202362. PMID 9989807.
Lee SW, Reimer CL, Fang L, et al. (2000). "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression.". Mol. Cell. Biol. 20 (5): 1723-32. PMID 10669749.
Yeh CT, Lu SC, Chen TC, et al. (2000). "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.". Cancer Res. 60 (17): 4697-700. PMID 10987270.
Song H, Hanlon N, Brown NR, et al. (2001). "Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.". Mol. Cell 7 (3): 615-26. PMID 11463386.
Wang H, Iakova P, Wilde M, et al. (2001). "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4.". Mol. Cell 8 (4): 817-28. PMID 11684017.
Donato JL, Ko J, Kutok JL, et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator.". J. Clin. Invest. 109 (1): 51-8. PMID 11781350.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yeh CT, Lu SC, Chao CH, Chao ML (2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant.". Biochem. Biophys. Res. Commun. 305 (2): 311-4. PMID 12745075.
Niculescu MD, Yamamuro Y, Zeisel SH (2004). "Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene.". J. Neurochem. 89 (5): 1252-9. doi:10.1111/j.1471-4159.2004.02414.x. PMID 15147518.
Chinami M, Yano Y, Yang X, et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.". J. Biol. Chem. 280 (17): 17235-42. doi:10.1074/jbc.M413437200. PMID 15671017.
Hsieh MJ, Yao YL, Lai IL, Yang WM (2006). "Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1.". Biochem. Biophys. Res. Commun. 349 (2): 573-81. doi:10.1016/j.bbrc.2006.08.064. PMID 16945326.
Okamoto K, Kitabayashi I, Taya Y (2006). "KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction.". Biochem. Biophys. Res. Commun. 351 (1): 216-22. doi:10.1016/j.bbrc.2006.10.022. PMID 17056014.