CDKL2

From Wikipedia, the free encyclopedia

Cyclin-dependent kinase-like 2 (CDC2-related kinase)

Identifiers

CDKL2; KKIAMRE; P56

External IDs

OMIM: 603442 MGI: 1858227 HomoloGene: 55793

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • signal transduction • sex differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003948 (mRNA)
NP_003939 (protein)

NM_016912 (mRNA)
NP_058608 (protein)

Location

Chr 4: 76.72 - 76.77 Mb

Chr 5: 93.08 - 93.12 Mb

Pubmed search

[1]

[2]

Cyclin-dependent kinase-like 2 (CDC2-related kinase), also known as CDKL2, is a human gene.^[1]

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase).

[edit] Further reading

Marracci GH, Marquardt WE, Strehlow A, et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).". Biochem. Biophys. Res. Commun. 344 (3): 963-71. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
Sarkar SN, Peters KL, Elco CP, et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.". Nat. Struct. Mol. Biol. 11 (11): 1060-7. doi:10.1038/nsmb847. PMID 15502848.
Tao J, Van Esch H, Hagedorn-Greiwe M, et al. (2005). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation.". Am. J. Hum. Genet. 75 (6): 1149-54. doi:10.1086/426460. PMID 15499549.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Taglienti CA, Wysk M, Davis RJ (1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE.". Oncogene 13 (12): 2563-74. PMID 9000130.
Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors.". J. Biol. Chem. 270 (16): 9115-20. PMID 7721825.