CDK5RAP3

From Wikipedia, the free encyclopedia

CDK5 regulatory subunit associated protein 3

Identifiers

CDK5RAP3; C53; HSF-27; IC53; MST016; OK/SW-cl.114

External IDs

OMIM: 608202 MGI: 1933126 HomoloGene: 12718

Gene ontology
Molecular Function:	• protein binding • neuronal Cdc2-like kinase binding
Cellular Component:	• cellular_component
Biological Process:	• regulation of cyclin-dependent protein kinase activity • brain development • cell proliferation • regulation of neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025197 (mRNA)
NP_079473 (protein)

NM_030248 (mRNA)
NP_084524 (protein)

Location

Chr 17: 43.4 - 43.41 Mb

Chr 11: 96.72 - 96.73 Mb

Pubmed search

[1]

[2]

CDK5 regulatory subunit associated protein 3, also known as CDK5RAP3, is a human gene.^[1]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ching YP, Qi Z, Wang JH (2000). "Cloning of three novel neuronal Cdk5 activator binding proteins.". Gene 242 (1-2): 285–94. PMID 10721722.
Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator.". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
Ching YP, Pang AS, Lam WH, et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor.". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
Chen J, Liu B, Liu Y, et al. (2002). "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.". Biochem. Biophys. Res. Commun. 294 (1): 161–6. doi:10.1016/S0006-291X(02)00446-1. PMID 12054757.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Xie YH, He XH, Tang YT, et al. (2003). "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein.". Cell Res. 13 (2): 83–91. doi:10.1038/sj.cr.7290153. PMID 12737517.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cen H, Zheng S, Fang YM, et al. (2004). "Induction of HSF1 expression is associated with sporadic colorectal cancer.". World J. Gastroenterol. 10 (21): 3122–6. PMID 15457556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jiang H, Luo S, Li H (2005). "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.". J. Biol. Chem. 280 (21): 20651–9. doi:10.1074/jbc.M413431200. PMID 15790566.
Yin X, Warner DR, Roberts EA, et al. (2005). "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53.". Int. J. Mol. Med. 16 (2): 251–6. PMID 16012757.
Wang J, He X, Luo Y, Yarbrough WG (2006). "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.". Biochem. J. 393 (Pt 2): 489–501. doi:10.1042/BJ20050960. PMID 16173922.
Kim E, Chen F, Wang CC, Harrison LE (2006). "CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation.". Int. J. Oncol. 28 (1): 191–4. PMID 16327995.
Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.". Mol. Psychiatry 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Stav D, Bar I, Sandbank J (2007). "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma.". Int. J. Biol. Markers 22 (2): 108–13. PMID 17549666.
Wang J, An H, Mayo MW, et al. (2007). "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.". Cancer Cell 12 (3): 239–51. doi:10.1016/j.ccr.2007.07.002. PMID 17785205.